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  2. CA
  3. San Francisco
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For Lease

221 Main

221 Main Street, San Francisco, CA 94105

16,114

SF Available

Rental Details

  • Number of spaces 2
  • Total square feet available 16,114 SF
  • For Lease Contact for pricing
  • Space Types General Office, Creative Office
  • Date Updated Apr 6, 2026
Want more info on this listing?

Reach out to the broker for more info on lease terms and amenities

True

For Lease 2 Spaces Available

#1650

  • Space Type General Office
  • Lease Rate Contact for pricing
  • Total Space Available 12,012 SF
  • Floor 16
  • Divisible Space 12,012 - 12,012 SF
  • Available Date Immediate
  • Renewal Option Yes
  • Sublease No

17 private offices

 

2 large conference rooms

 

2 medium conference rooms

 

Kitchenette/break area

 

Open Area | 25 6’ x 8’ Workstations

 

Copy Area

 

Storage Room

 

Wellness Room

 

Partically Exposed Ceilings

broker
Wesley Powell

Jones Lang LaSalle

broker
Steve Anderson

Jones Lang LaSalle

broker
Lexi Castellino

Jones Lang LaSalle

#400

  • Space Type Creative Office
  • Lease Rate Contact for pricing
  • Total Space Available 4,102 SF
  • Floor 4
  • Divisible Space 4,102 - 4,102 SF
  • Available Date Immediate
  • Renewal Option Yes
  • Sublease No

Brand New Spec Suite Underway!

 

Creative Ceilings

 

Fully Furnished

 

6 Private Offices

 

1 Large Conference Room

 

Phone Room

 

Kitchen

 

Break Area

 

Reception

broker
Wesley Powell

Jones Lang LaSalle

broker
Steve Anderson

Jones Lang LaSalle

broker
Lexi Castellino

Jones Lang LaSalle

Contacts

broker
Wesley Powell

Jones Lang LaSalle

broker
Steve Anderson

Jones Lang LaSalle

broker
Jason Volpe

Jones Lang LaSalle

broker
John Roskos

Jones Lang LaSalle

broker
Lexi Castellino

Jones Lang LaSalle

Building Details

  • For Lease Contact for pricing
  • Property Type Office - General Office
  • Property Size 387,943 SF
  • Lot Size 1.08 Acre
  • Parking Spaces Avail. 108
  • Parking Ratio 0.28 / 1,000 SF
  • Property Tenancy Multi-Tenant
  • LEED Certified Platinum
  • Building Class A
  • Year Built 1973
  • Date Updated Apr 6, 2026

Getting Around

  • Walk Score ®

    Walker's Paradise (97)
  • Transit Score ®

    Rider's Paradise (100)
  • Bike Score ®

    Very Bikeable (80)
Powered by Walk Score ®

Location

  • City San Francisco, CA
  • Neighborhood South Beach
  • Zip Code 94105
  • Market San Francisco
  • Map
  • Street

Points of Interest

Taxi Stand at Farmers Market near Ferry Building

0.23 miles

Taxi Stand at Salesforce Transit Center

0.27 miles

Market Street & Drumm Street

0.31 miles

Market Street & Main Street

0.31 miles

California Street & Drumm Street

0.33 miles

Taxi Stand at 101 California St Building (along Davis St)

0.35 miles

Taxi Stand at Hyatt Regency (along Drumm St)

0.36 miles

California Street & Davis Street

0.38 miles

Market Street & Battery Street

0.38 miles

Chevron

1.14 miles

EVgo

1.50 miles

Volta HQ Charging Station

1.62 miles

76

1.64 miles

Standard

1.67 miles

Tesla Destination Charger

2.04 miles

Arco

2.16 miles

Electrify America

2.19 miles

Rivian Waypoints

2.27 miles

ace parking

0.50 miles

Palace Garage

0.51 miles

Embarcadero Center 1 Parking

0.53 miles

SFMOMA Garage

0.53 miles

Golden Gateway Garage

0.54 miles

Moscone Center Garage

0.56 miles

550 California Street Parking Garage

0.66 miles

Jessie Square Garage

0.68 miles

The White House Garage

0.68 miles

Zipcar

0.80 miles

Getaround

0.80 miles

City Car Share

0.80 miles

Avis

0.80 miles

Budget

0.80 miles

Alamo

0.96 miles

Hertz

1.01 miles

National & Alamo

1.03 miles

Thrifty

1.05 miles

Prospect

0.07 miles

Proper Food

0.08 miles

Mau

0.09 miles

SOMA Eats

0.10 miles

Nick The Greek

0.11 miles

Tokyo Express

0.12 miles

Epic Steak

0.15 miles

Ozumo

0.16 miles

Waterbar

0.16 miles

Safeway

0.57 miles

Chaat Corner Indian Grocery

0.60 miles

Crocker Galleria

0.60 miles

Metreon

0.74 miles

Target

0.75 miles

Whole Foods Market

0.77 miles

Neiman Marcus

0.77 miles

Ross

0.80 miles

Trader Joe's

0.82 miles

Spring Fertility

0.19 miles

San Francisco Fire Station 35

0.20 miles

Walgreens

0.30 miles

Concentra Urgent Care

0.36 miles

Care Essentials

0.39 miles

Focus Clinic

0.52 miles

San Francisco VA Medical Center - Downtown Clinic

0.61 miles

San Francisco Fire Station 13

0.62 miles

One Medical

0.66 miles

221 Main Street Listing Summary

  • Office Space Available at 221 Main Street

    Office space currently available at 221 Main Street adds up to a total of 16,114 square feet across 2 listing(s). The largest individual space listed offers 12,012 square feet. Property use types available for lease at this property include: general office and creative office.

  • Learn More about 221 Main Street

    221 Main Street is located in the San Francisco market and pertains to the 94105 zip code. The property incorporates a total of 16,114 square feet of space. 221 Main Street features a parking ratio of 0.28 / 1,000 SF, offering a total of 108 parking spaces. 221 Main Street was built in 1973.

    Interested in researching more about this property? Access in-depth research on 221 Main Street, including ownership details, transaction history, property characteristics, taxes, mortgage data, violations and more by creating a free account and viewing the full property report.

  • Get to Know the Neighborhood

    In the South Beach neighborhood, where 221 Main Street is located, you can currently find 173 office space(s) for rent. In total, this amounts to 3,242,211 square feet of available office space for lease opportunities.

Contact 221 Main
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  2. 2Extra information
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