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For Lease

Two Discovery Square

415 2nd Ave SW, Rochester, MN 55902

63,556

SF Available

Two Discovery Square offers life science innovators a state-of-the-art 125,000 square foot facility designed for groundbreaking research. As part of Mayo Clinic’s ecosystem, tenants gain access to specialized research cores, cuttingedge technology, and expert guidance. The facility seamlessly integrates with Mayo’s unique data pipelines and the Discovery and Translation Alliance spectrum, accelerating the path from idea to real-world medical solutions

 

Rental Details

  • Number of spaces 5
  • Total square feet available 63,556 SF
  • For Lease Contact for pricing
  • Space Types Office
  • Date Updated Jan 27, 2026
Want more info on this listing?

Reach out to the broker for more info on lease terms and amenities

True

For Lease 5 Spaces Available

1st Floor

  • Space Type Office
  • Lease Rate Contact for pricing
  • Total Space Available 1,163 SF
  • Floor 1
  • Divisible Space 1,163 - 1,163 SF
  • Available Date Immediate
  • Renewal Option Yes
  • Sublease No
broker
Jessica Mogilka

Jones Lang LaSalle

broker
Will McArdle

Jones Lang LaSalle

2nd Floor

  • Space Type Office
  • Lease Rate Contact for pricing
  • Total Space Available 13,032 SF
  • Floor 2
  • Divisible Space 13,032 - 13,032 SF
  • Available Date Immediate
  • Renewal Option Yes
  • Sublease No
broker
Jessica Mogilka

Jones Lang LaSalle

broker
Will McArdle

Jones Lang LaSalle

3rd Floor

  • Space Type Office
  • Lease Rate Contact for pricing
  • Total Space Available 21,544 SF
  • Floor 3
  • Divisible Space 21,544 - 21,544 SF
  • Available Date Immediate
  • Renewal Option Yes
  • Sublease No
broker
Jessica Mogilka

Jones Lang LaSalle

broker
Will McArdle

Jones Lang LaSalle

4th Floor

  • Space Type Office
  • Lease Rate Contact for pricing
  • Total Space Available 5,350 SF
  • Floor 4
  • Divisible Space 5,350 - 5,350 SF
  • Available Date Immediate
  • Renewal Option Yes
  • Sublease No
broker
Jessica Mogilka

Jones Lang LaSalle

broker
Will McArdle

Jones Lang LaSalle

5th Floor

  • Space Type Office
  • Lease Rate Contact for pricing
  • Total Space Available 22,467 SF
  • Floor 5
  • Divisible Space 22,467 - 22,467 SF
  • Available Date Immediate
  • Renewal Option Yes
  • Sublease No
broker
Jessica Mogilka

Jones Lang LaSalle

broker
Will McArdle

Jones Lang LaSalle

Contacts

broker
Jessica Mogilka

Jones Lang LaSalle

broker
Will McArdle

Jones Lang LaSalle

Building Details

  • For Lease Contact for pricing
  • Property Type Office
  • Property Size 125,000 SF
  • Date Updated Jan 27, 2026

Getting Around

  • Walk Score ®

    Walker's Paradise (92)
  • Bike Score ®

    Very Bikeable (84)
Powered by Walk Score ®

Location

  • City Rochester, MN
  • Zip Code 55902
  • Market Minneapolis St Paul

Points of Interest

Electric Car Charging Station

0.32 miles

Holiday

0.47 miles

Marathon

0.86 miles

Kwik Trip

0.87 miles

Tesla Supercharger

0.88 miles

Baraka Super Gasoline

1.04 miles

Nissan

3.94 miles

Ford

4.30 miles

ChargePoint

4.40 miles

3rd Street Parking Ramp

0.14 miles

Soldiers Field Memorial

0.20 miles

Baldwin Parking Ramp

0.20 miles

Zumbro Market Lot

0.24 miles

2nd Street Parking Ramp

0.29 miles

Mayo Clinic East Shuttle Lot 35

0.31 miles

Damon Parking Ramp

0.31 miles

Government Center South Lot

0.32 miles

Kahler Hotel Parking Ramp

0.32 miles

Mister Car Wash

0.84 miles

Kwik Trip Car Wash

1.43 miles

Car Wash USA

1.49 miles

Southpoint Detailing

1.87 miles

Holiday Car Wash

1.97 miles

Tommy's Express Car Wash

2.85 miles

Enterprise

3.04 miles

Simoniz Car Wash

3.08 miles

Kuehn Rental

4.39 miles

Fuzzy's Italian Ice

0.13 miles

Twigs

0.13 miles

The Loop

0.14 miles

Bleu Duck Kitchen

0.14 miles

The Half-Barrel

0.16 miles

ThaiPop

0.19 miles

Mango Thai

0.20 miles

Newt's

0.20 miles

Terza

0.22 miles

University Square

0.31 miles

Counterpoint

0.32 miles

Soldiers Field Plaza

0.37 miles

King's Row

0.45 miles

ALDI

0.88 miles

Crossroads

0.90 miles

Hy-Vee

0.92 miles

Crossroads Shopping Center

0.94 miles

Fresh Thyme

1.06 miles

Mayo Clinic

0.27 miles

Rochester Police Department

0.29 miles

Olmsted County Sheriff's Office

0.30 miles

Mayo Clinic Hospital Methodist Campus

0.41 miles

Olmsted Medical Center Southeast

0.54 miles

Olmsted Medical Center

0.57 miles

Mayo Clinic Saint Marys Campus

0.71 miles

Mayo Eugenio Litta Children's Hospital

0.83 miles

Walgreens

0.91 miles

415 2nd Ave SW Listing Summary

  • Office Space Available at 415 2nd Ave SW

    Office space currently available at 415 2nd Ave SW adds up to a total of 63,556 square feet across 5 listing(s). The largest individual space listed offers 22,467 square feet. Property use types available for lease at this property include: office.

  • Learn More about 415 2nd Ave SW

    415 2nd Ave SW is located in the Minneapolis St Paul market and pertains to the 55902 zip code. The property incorporates a total of 63,556 square feet of space.

    Interested in researching more about this property? Access in-depth research on 415 2nd Ave SW, including ownership details, transaction history, property characteristics, taxes, mortgage data, violations and more by creating a free account and viewing the full property report.

Contact Two Discovery Square
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