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For Lease

John P. McGovern Campus

2450 Holcombe Blvd, Houston, TX 77021

135,554

SF Available

Rental Details

  • Number of spaces 11
  • Total square feet available 135,554 SF
  • For Lease Contact for pricing
  • Space Types Life Sciences
  • Date Updated May 21, 2026
Want more info on this listing?

Reach out to the broker for more info on lease terms and amenities

True

For Lease 11 Spaces Available

#1330

  • Space Type Life Sciences
  • Lease Rate Contact for pricing
  • Total Space Available 3,267 SF
  • Divisible Space 3,267 - 3,267 SF
  • Available Date Immediate
  • Renewal Option Yes
  • Sublease No
broker
Lisa Bovermann

Transwestern

broker
Eric Johnson

Transwestern

broker
Kaitlyn Harp

Transwestern

#1340A

  • Space Type Life Sciences
  • Lease Rate Contact for pricing
  • Total Space Available 4,070 SF
  • Divisible Space 4,070 - 4,070 SF
  • Available Date Immediate
  • Renewal Option Yes
  • Sublease No
broker
Lisa Bovermann

Transwestern

broker
Eric Johnson

Transwestern

broker
Kaitlyn Harp

Transwestern

#1340B

  • Space Type Life Sciences
  • Lease Rate Contact for pricing
  • Total Space Available 1,560 SF
  • Divisible Space 1,560 - 1,560 SF
  • Available Date Immediate
  • Renewal Option Yes
  • Sublease No
broker
Lisa Bovermann

Transwestern

broker
Eric Johnson

Transwestern

broker
Kaitlyn Harp

Transwestern

#1410

  • Space Type Life Sciences
  • Lease Rate Contact for pricing
  • Total Space Available 6,146 SF
  • Divisible Space 6,146 - 6,146 SF
  • Available Date Immediate
  • Renewal Option Yes
  • Sublease No
broker
Lisa Bovermann

Transwestern

broker
Eric Johnson

Transwestern

broker
Kaitlyn Harp

Transwestern

#1600

  • Space Type Life Sciences
  • Lease Rate Contact for pricing
  • Total Space Available 28,070 SF
  • Floor 1
  • Divisible Space 28,070 - 28,070 SF
  • Available Date Immediate
  • Renewal Option Yes
  • Sublease No
broker
Lisa Bovermann

Transwestern

broker
Eric Johnson

Transwestern

broker
Kaitlyn Harp

Transwestern

#1630

  • Space Type Life Sciences
  • Lease Rate Contact for pricing
  • Total Space Available 15,890 SF
  • Floor 1
  • Divisible Space 15,890 - 15,890 SF
  • Available Date Immediate
  • Renewal Option Yes
  • Sublease No
broker
Lisa Bovermann

Transwestern

broker
Eric Johnson

Transwestern

broker
Kaitlyn Harp

Transwestern

#2100

  • Space Type Life Sciences
  • Lease Rate Contact for pricing
  • Total Space Available 51,940 SF
  • Floor 2
  • Divisible Space 51,940 - 51,940 SF
  • Available Date Immediate
  • Renewal Option Yes
  • Sublease No
broker
Lisa Bovermann

Transwestern

broker
Eric Johnson

Transwestern

broker
Kaitlyn Harp

Transwestern

#2220

  • Space Type Life Sciences
  • Lease Rate Contact for pricing
  • Total Space Available 5,215 SF
  • Floor 2
  • Divisible Space 5,215 - 5,215 SF
  • Available Date Immediate
  • Renewal Option Yes
  • Sublease No
broker
Lisa Bovermann

Transwestern

broker
Eric Johnson

Transwestern

broker
Kaitlyn Harp

Transwestern

#2230

  • Space Type Life Sciences
  • Lease Rate Contact for pricing
  • Total Space Available 2,532 SF
  • Floor 2
  • Divisible Space 2,532 - 2,532 SF
  • Available Date Immediate
  • Renewal Option Yes
  • Sublease No
broker
Lisa Bovermann

Transwestern

broker
Eric Johnson

Transwestern

broker
Kaitlyn Harp

Transwestern

#2240

  • Space Type Life Sciences
  • Lease Rate Contact for pricing
  • Total Space Available 3,859 SF
  • Floor 2
  • Divisible Space 3,859 - 3,859 SF
  • Available Date Immediate
  • Renewal Option Yes
  • Sublease No
broker
Lisa Bovermann

Transwestern

broker
Eric Johnson

Transwestern

broker
Kaitlyn Harp

Transwestern

#2250

  • Space Type Life Sciences
  • Lease Rate Contact for pricing
  • Total Space Available 13,005 SF
  • Floor 2
  • Divisible Space 13,005 - 13,005 SF
  • Available Date Immediate
  • Renewal Option Yes
  • Sublease No
broker
Lisa Bovermann

Transwestern

broker
Eric Johnson

Transwestern

broker
Kaitlyn Harp

Transwestern

Contacts

broker
Eric Johnson

Transwestern

broker
Lisa Bovermann

Transwestern

broker
Kaitlyn Harp

Transwestern

broker
Emily Gwaltney

Texas Medical Center

Building Details

  • For Lease Contact for pricing
  • Property Type Office - R&D - Office
  • Property Size 638,834 SF
  • Lot Size 21.44 Acre
  • Parking Spaces Avail. 785
  • Parking Ratio 1.23 / 1,000 SF
  • Property Tenancy Multi-Tenant
  • Building Class B
  • Year Built 1948
  • Date Updated May 21, 2026

Getting Around

  • Walk Score ®

    Somewhat Walkable (52)
  • Transit Score ®

    Some Transit (48)
  • Bike Score ®

    Bikeable (68)
Powered by Walk Score ®

Location

  • City Houston, TX
  • Neighborhood MacGregor
  • Zip Code 77021
  • Market Houston
  • Map
  • Street

Points of Interest

Dryden/TMC

1.15 miles

TMC Transit Center

1.18 miles

M. D. Anderson Station

1.25 miles

Hermann Park/Rice U

1.32 miles

Museum District (northbound)

1.49 miles

Museum District (southbound)

1.54 miles

Fannin South

2.36 miles

UH South/University Oaks

2.69 miles

Downtown Transit Center

3.35 miles

Shell

0.45 miles

Blink

0.90 miles

Exxon

0.90 miles

Shop and Go

1.10 miles

Sunoco

1.36 miles

Valero

1.39 miles

Tesla Supercharger

5.42 miles

ChargePoint

5.70 miles

eVgo

8.31 miles

Texas Medical Center Garage 10

0.75 miles

Texas Medical Center Garage 5

0.76 miles

Garage 17

0.77 miles

Parking Lot I

0.81 miles

Texas Medical Center Garage 6

0.84 miles

Parking Lot H

0.89 miles

Texas Medical Center Garage 4

0.95 miles

Parking Lot G

0.97 miles

Parking Lot F

0.99 miles

Mister Car Wash

1.66 miles

Enterprise Rent-a-car

1.79 miles

Avis

1.81 miles

Shine AutoSpa Midtown

1.89 miles

Carriage Glass & Detail

2.23 miles

The Car Wash

2.35 miles

Joe's Car Wash

3.24 miles

Hertz

3.29 miles

U-Haul

3.44 miles

Shipley Do-Nuts

0.43 miles

Burger King

0.43 miles

Abu Omar

0.89 miles

Chick-fil-A

0.90 miles

Texas Medical Center Commons

0.97 miles

Einstein Bros. Bagels

1.09 miles

McDonald's

1.10 miles

Domino's

1.12 miles

Jack in the Box

1.13 miles

ALDI

1.21 miles

Big Lots

1.98 miles

Kroger

2.00 miles

Fiesta Mart

2.11 miles

Target

2.27 miles

Randalls 1061

2.57 miles

Center & Kirby

2.87 miles

Trader Joe's

3.00 miles

Magick Cauldron

3.12 miles

Jamail Specialty Care Center

0.58 miles

Baylor College of Medicine McNair Campus

0.70 miles

Baylor College of Medicine Medical Center

0.74 miles

Ben Taub General Hospital

0.82 miles

UTHealth Harris County Psychiatric Center

0.82 miles

H-E-B Pharmacy

0.87 miles

University of Texas MD Anderson Cancer Center

0.89 miles

Texas Heart Institute - Denton A. Cooley Building

1.02 miles

Memorial Hermann-Texas Medical Center

1.03 miles

2450 Holcombe Blvd Listing Summary

  • Office Space Available at 2450 Holcombe Blvd

    Office space currently available at 2450 Holcombe Blvd adds up to a total of 135,554 square feet across 11 listing(s). The largest individual space listed offers 51,940 square feet. Property use types available for lease at this property include: life sciences.

  • Learn More about 2450 Holcombe Blvd

    2450 Holcombe Blvd is located in the Houston market and pertains to the 77021 zip code. The property incorporates a total of 135,554 square feet of space. 2450 Holcombe Blvd features a parking ratio of 1.23 / 1,000 SF, offering a total of 785 parking spaces. 2450 Holcombe Blvd was built in 1948.

    Interested in researching more about this property? Access in-depth research on 2450 Holcombe Blvd, including ownership details, transaction history, property characteristics, taxes, mortgage data, violations and more by creating a free account and viewing the full property report.

  • Get to Know the Neighborhood

    In the MacGregor neighborhood, where 2450 Holcombe Blvd is located, you can currently find 10 office space(s) for rent. In total, this amounts to 133,022 square feet of available office space for lease opportunities.

Contact John P. McGovern Campus
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