Sienna Medical Plaza | Medical Office Space Missouri City TX
8102 Hwy 6, Missouri City, TX 77459
18,400
SF AvailableNow leasing medical office space at Sienna Medical Plaza in Missouri City, TX—a high-demand submarket for healthcare-focused users. Schedule a tour today.
Sienna Medical Plaza is a newly delivered, two-story, 36,800 SF Class A medical office building strategically positioned along Highway 6 in the heart of the Sienna master-planned community in Missouri City, Texas. The property is purpose-built for healthcare and anchored by MD Anderson Cancer Center, which occupies the entire first floor, immediately establishing the building as a recognized medical destination within Fort Bend County.
The available opportunity consists of the full 18,400 SF second floor, offering a contiguous, efficient floor plate designed to accommodate specialty medical, imaging, infusion, oncology support, women’s health, surgical consult, therapy, and other referral-based healthcare providers. Elevator-served and fully sprinklered, the building provides institutional quality construction and professional lobby access, delivering the identity and functionality today’s medical operators require.
Sienna is one of the fastest-growing master-planned communities in the Houston MSA, with significant residential density and strong household incomes surrounding the site. The property benefits from direct exposure and access along Highway 6, a primary north-south arterial serving Missouri City and greater Fort Bend County. This corridor continues to experience sustained population growth, creating long-term demand for healthcare services and specialty providers.
The presence of MD Anderson on-site creates immediate referral synergy, daily patient traffic, and long-term stability for complementary medical users. Opportunities to lease directly above a nationally recognized healthcare institution within a newly constructed, Class A facility are rare in this submarket
Key features
- 18,400 SF Contiguous 2nd Floor Divisible for Strategic Users
- Anchored by MD Anderson Cancer Center (Entire 1st Floor Leased)
- Class A, Two-Story Purpose-Built Medical Construction
- Efficient Floor Plate Ideal for Specialty & Clinical Layouts
- Elevator-Served with Professional Healthcare Lobby
- Positioned Within Rapidly Expanding Sienna Master-Planned Community
- Prominent Highway 6 Visibility & Access
- Rare Institutional-Quality Medical Asset in Sienna Corridor
Rental Details
- Number of spaces 1
- Total square feet available 18,400 SF
- For Lease $36.00/SF/YR
- Space Types Medical Office
- Date Updated May 28, 2026
Reach out to the broker for more info on lease terms and amenities
True
For Lease 1 Space Available
2nd Floor Space Available |
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Contacts
Realty 1 Partners
Building Details
- For Lease $36.00/SF/YR
- Property Type Office - Medical Office
- Year Built 2025
- Date Updated May 28, 2026
Getting Around
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Walk Score ®
Car-Dependent (47) -
Bike Score ®
Somewhat Bikeable (41)
Location
- City Missouri City, TX
- Neighborhood Sienna Village Of Anderson Springs
- Zip Code 77459
- Market Houston
Points of Interest
H-E-B Fuel
0.82 miles
Shell
1.25 miles
Chevron
1.80 miles
Kroger
2.15 miles
Walmart
2.36 miles
eVgo
5.84 miles
Tesla Supercharger
5.95 miles
Richmond, TX Supercharger
8.91 miles
Blink
9.98 miles
Missouri City Park and Ride
5.90 miles
Sugar Land Parking Lot 3
6.42 miles
Sugar Land Parking Lot 4
6.43 miles
Albert & Mamie George Building Loading Dock
6.47 miles
Sugar Land Parking Lot 2
6.54 miles
Day Lot 3
6.56 miles
Brazos Hall Loading Dock
6.57 miles
Day Lot
6.58 miles
Sugar Land Parking Lot 1
6.59 miles
Enterprise
6.50 miles
Oasis Super Wash
7.15 miles
Circle K
8.98 miles
Express Car Wash
9.48 miles
Brookstreet BBQ
0.69 miles
Pizza Hut Delivery
0.76 miles
Whataburger
0.77 miles
Billy's Donuts
0.83 miles
Shipley Do-Nuts
0.94 miles
BurgerIM
1.05 miles
Smoothie King
1.06 miles
Chick-fil-A
1.14 miles
IHOP
1.19 miles
H-E-B
0.90 miles
Kroger
1.66 miles
Goodwill Retail Store
1.66 miles
Target
1.86 miles
Walmart Supercenter
2.01 miles
Kohl's
2.34 miles
Welfresh Market
3.36 miles
Fiesta Mart Supermarket
3.90 miles
Big Lots
4.39 miles
Missouri City Fire and Rescue Services Station 4
1.07 miles
Walgreens
1.72 miles
CVS Pharmacy
1.88 miles
Hospitality Urgent Care
2.29 miles
Walmart Pharmacy
2.35 miles
Fresenius Kidney Care Fort Bend
2.72 miles
Missouri City Police Department
2.80 miles
Missouri City Fire and Rescue Services Station 1
2.82 miles
Fresenius Kidney Care Missouri City
2.86 miles
8102 Hwy 6 Listing Summary
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Office Space Available at 8102 Hwy 6
Office space currently available at 8102 Hwy 6 adds up to a total of 18,400 square feet across 1 listing(s). The largest individual space listed offers 18,400 square feet. Property use types available for lease at this property include: medical office.
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Learn More about 8102 Hwy 6
8102 Hwy 6 is located in the Houston market and pertains to the 77459 zip code. The property incorporates a total of 18,400 square feet of space. 8102 Hwy 6 was built in 2025.
Interested in researching more about this property? Access in-depth research on 8102 Hwy 6, including ownership details, transaction history, property characteristics, taxes, mortgage data, violations and more by creating a free account and viewing the full property report.
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Get to Know the Neighborhood
In the Sienna Village Of Anderson Springs neighborhood, where 8102 Hwy 6 is located, you can currently find 4 office space(s) for rent. In total, this amounts to 20,850 square feet of available office space for lease opportunities.
Realty 1 Partners
