5406 US-280
5406 US-280, Birmingham, AL 35242
Join Andrews Sports Medicine, Skin Wellness Dermatology, ENT for Kids, and Birmingham Orthodontics, in this premier medical location on Highway 280.
The Crossroads at Greystone offers a convenient, neighborhood center setting for your next location. Building signage and ample parking in a drive-up setting provides an easy experience for patients and visitors.
Multiple suite sizes are available and build out packages can be customized to your exact layout needs.
85,500 vehicles per day on Highway 280
18,800 vehicles per day on Highway 119 (Cahaba Valley Road)
Excellent signage (building and monument)
Drive up parking for a convenient patient experience
Multiple ingress/egress points and traffic light access to Highway 280
Convenient to Birmingham’s major neighborhoods: Inverness, Meadowbrook, Greystone and continued growth down Highway 280
Rental Details
- Number of spaces 5
- Total square feet available 13,345 SF
- For Lease $24.00/SF/YR
- Space Type Retail
- Lease Type NNN
- Latest Update Jul 29, 2026
Reach out to the broker for more info on lease terms and amenities
True
5 Spaces Available
| Space Name | Space Type | Lease Rate | Total Space | Floor | Lease Type | |
|---|---|---|---|---|---|---|
| #5 | Retail | $24.00/SF/YR | 6,145 SF | - | NNN | |
| #B101 | Retail | $24.00/SF/YR | 3,600 SF | - | NNN | |
| #B105 | Retail | $24.00/SF/YR | 1,200 SF | - | NNN | |
| #D112 | Retail | $24.00/SF/YR | 1,200 SF | - | NNN | |
| #D113 | Retail | $24.00/SF/YR | 1,200 SF | - | NNN |
#5
- Space Type
- Retail
- Lease Rate
- $24.00/SF/YR
- Total Space
- 6,145 SF
- Lease Type
- NNN
#B101
- Space Type
- Retail
- Lease Rate
- $24.00/SF/YR
- Total Space
- 3,600 SF
- Lease Type
- NNN
#B105
- Space Type
- Retail
- Lease Rate
- $24.00/SF/YR
- Total Space
- 1,200 SF
- Lease Type
- NNN
#D112
- Space Type
- Retail
- Lease Rate
- $24.00/SF/YR
- Total Space
- 1,200 SF
- Lease Type
- NNN
#D113
- Space Type
- Retail
- Lease Rate
- $24.00/SF/YR
- Total Space
- 1,200 SF
- Lease Type
- NNN
Contacts
Lincoln Holdings
Building Details
- For Lease $24.00/SF/YR
- Property Type Retail
- Property Size 13,345 SF
- Additional Rent Price on request
- Date Updated Jul 29, 2026
Location
- City Birmingham, AL
- Neighborhood Greystone
- Zip Code 35242
- Market Birmingham
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Walk score 54/100 Somewhat Walkable -
Bike score 39/100 Somewhat Bikeable
Points of Interest
Shell
0.08 miles
Cowboys
0.74 miles
BP
1.61 miles
Chevron
1.77 miles
1314- Dunnavant Valley Chevron
2.43 miles
Tesla Supercharger
2.48 miles
ChargePoint
7.39 miles
Mountain Brook, AL Supercharger
7.58 miles
Leeds, AL Supercharger
9.99 miles
Grandview Emergency Parking
2.83 miles
Grandview Parking Deck
2.94 miles
Parking Deck
3.23 miles
North Trailhead Parking
4.55 miles
School bus parking lot
7.03 miles
Pizitz Parking lot
7.13 miles
Track and Soccer Stadium Parking
7.68 miles
Publix
0.28 miles
Walmart Supercenter
0.41 miles
Sprouts Farmers Market
0.73 miles
TJ Maxx
1.26 miles
Winn-Dixie
1.35 miles
Kohl's
1.47 miles
The Fresh Market
1.69 miles
ALDI
1.93 miles
Piggly Wiggly
2.39 miles
Target
2.47 miles
Listing Summary
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The Price for Retail Space at 5406 US-280
The cost of renting retail space in a property highly depends on features such as its location, parking availability and type of retail space, or advantages and features that might be unique to it. When it comes to 5406 US-280, asking rent starts at $$24.00/SF/YR per square foot.
5406 US-280 is located in the Greystone neighborhood, which is home to a total of 14 retail listing(s). In the case of most businesses that need retail space, access to potential customers is critical. This can come in the form of retail space situated in high-traffic pedestrian areas, or convenient suburban locations with good public transport or plenty of parking. Reach out to the listing broker for information on best parking and other access options at or near the property.
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Retail Space Options Available at 5406 US-280
The property exclusively contains Retail space totaling 13,345 square feet. The leasing opportunity here is available under NNN lease terms.
In addition to retail space type, you will also need to consider the space size that you need for your business to operate at its best. You will find 5 retail space(s) ranging from 1,000 square feet to 10,000 square feet at 5406 US-280, which can serve small or medium retail businesses that are planning to accommodate growth throughout the duration of their lease at this address. For more information or to schedule a tour of the property, reach out using the contact form on this page to get in touch with a broker.
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Get to Know the Retail Scene in the Greystone Neighborhood
5406 US-280 is located in the Greystone neighborhood of Birmingham. The Greystone retail market offers 14 retail listing(s), representing a total of 32,062 square feet of retail space for lease.
The most common retail type in the Greystone neighborhood is General Office, of which the market currently offers 8 space(s).
When looking for retail space for your company, picking the right area is essential. Some neighborhoods have a long history of being top shopping destinations in general, while others gain a reputation for strongly representing a specific type of business. In addition to knowing the reputation of your chosen business location neighborhood, it’s also important to know your customer base. For instance, the average Greystone resident is 44 years old, and the median household income here is $117,047 per year.
Lincoln Holdings
