Map of Property

For Lease

2100 SIXTEENTH

2100 16th Avenue South , Birmingham, AL 35205

44,220

SF Available
2100 SIXTEENTH is prominently located in Birmingham’s Southside/Medical Center submarket, offering convenient access to UAB, UAB St. Vincent’s Hospital, and Children’s of Alabama, with direct connectivity to the Red Mountain Expressway. The property is under new ownership and scheduled for exterior and common area renovations in Spring 2026. With strong surrounding institutional anchors, on‑site parking, and flexible layouts, the building is well positioned for medical and professional office tenants.2100 SIXTEENTH is prominently located in Birmingham’s Southside/Medical Center submarket, offering convenient access to UAB, St. Vincent’s Hospital, and Children’s of Alabama, with direct connectivity to the Red Mountain Expressway. The property is under new ownership and scheduled for exterior and common area renovations in Spring 2026. With strong surrounding institutional anchors, on‑site parking, and flexible layouts, the building is well positioned for medical and professional office tenants.

Key features

  • 2100 SIXTEENTH is under new ownership
  • Building signage available
  • Conveniently located in a prime Southside / Medical Center location
  • Easy access to Red Mountain Expressway
  • Exterior & common area improvements coming Spring 2026
  • Full-floor availability
  • Large parking garage with direct building access and on-site parking lot
  • Near UAB, St. Vincent’s & Children’s Hospital
  • Well suited for medical and office users

Rental Details

  • Number of spaces 12
  • Total square feet available 44,220 SF
  • For Lease Contact for pricing
  • Space Types Office, Medical Office
  • Lease Type Full Service
  • Date Updated May 14, 2026
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Reach out to the broker for more info on lease terms and amenities

For Lease 12 Spaces Available

Contacts

Philip A. Currie

JH Berry Commercial Real Estate

Building Details

  • For Lease Contact for pricing
  • Property Type Office - Medical Office
  • Property Size 53,170 SF
  • Lot Size 1.26 Acre
  • Building Class B
  • Year Built 1982
  • Date Updated May 14, 2026

Attachments

Getting Around

  • Walk Score ®

    Very Walkable (86)

  • Transit Score ®

    Some Transit (35)

  • Bike Score ®

    Somewhat Bikeable (33)
Powered by Walk Score ®

Location

  • City Birmingham, AL
  • Neighborhood Five Points South
  • Zip Code 35205
  • Market Birmingham

Points of Interest

Shell

0.37 miles

BP

0.92 miles

Mac's One Stop

1.00 miles

Texaco

1.00 miles

Mountain Brook, AL Supercharger

1.33 miles

Tesla Supercharger

2.17 miles

ChargePoint

7.03 miles

St. Vincent's Child Care Parking

0.43 miles

32-F

0.46 miles

10th Ave Parking Deck

0.48 miles

UAB G-2

0.50 miles

UAB G-3

0.50 miles

St. Vincent's West Parking Lot

0.53 miles

Zone A-2

0.53 miles

UAB G-7

0.57 miles

UAB Parking Deck Zone A

0.57 miles

Budget

1.07 miles

Etheridge Brothers Car Wash

1.65 miles

Marc 1 Car Wash

2.29 miles

Enterprise

2.44 miles

Dollar

4.33 miles

Goo Goo Express Car Wash

5.55 miles

Splash N Go Car Wash

6.33 miles

Mister Car Wash

6.73 miles

Chevron Car Wash

7.29 miles

Ocean

0.23 miles

Mellow Mushroom

0.27 miles

Chick-fil-A

0.27 miles

Galley & Garden

0.29 miles

Taj India

0.32 miles

The Original Pancake House

0.33 miles

IKKO Japanese Ramen and Sushi

0.35 miles

Golden Temple

0.35 miles

Waffle House

0.36 miles

Piggly Wiggly

1.31 miles

GreenWise Market at Lane Parke

1.33 miles

The Fresh Market

2.27 miles

Target

2.29 miles

Gordo's Mexican food

2.34 miles

Valley Avenue Plaza

2.35 miles

Walmart Neighborhood Market

2.64 miles

Super Ofertas

2.68 miles

Big Lots

2.78 miles

Alabama Ophthalmology Associates

0.47 miles

UAB Personal Health Clinic

0.57 miles

Walgreens

0.59 miles

Spain and McDonald Clinic

0.59 miles

CVS Pharmacy

0.67 miles

Davita Dialysis

0.68 miles

University of Alabama at Birmingham Police Department

0.69 miles

UAB Liver Center

0.71 miles

VA Medical Center

0.74 miles

2100 16th Avenue South Listing Summary

  • Office Space Available at 2100 16th Avenue South

    Office space currently available at 2100 16th Avenue South adds up to a total of 44,220 square feet across 12 listing(s). The largest individual space listed offers 6,559 square feet. Property use types available for lease at this property include: office and medical office.

  • Learn More about 2100 16th Avenue South

    2100 16th Avenue South is located in the Birmingham market and pertains to the 35205 zip code. The property incorporates a total of 44,220 square feet of space. 2100 16th Avenue South was built in 1982.

    Interested in researching more about this property? Access in-depth research on 2100 16th Avenue South , including ownership details, transaction history, property characteristics, taxes, mortgage data, violations and more by creating a free account and viewing the full property report.

  • Get to Know the Neighborhood

    In the Five Points South neighborhood, where 2100 16th Avenue South is located, you can currently find 50 office space(s) for rent. In total, this amounts to 200,760 square feet of available office space for lease opportunities.

Contact Listing Broker
Philip A. Currie

JH Berry Commercial Real Estate

  1. 1Main information
  2. 2Extra information
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