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For Lease

Protective Center

2801 Hwy 280 S, Birmingham, AL 35223

45,610

SF Available

Welcome to Protective Center, the most iconic and beautiful corporate campus in Birmingham. The property is perfectly located in the heart of Birmingham’s most desirable Midtown office submarket. The Protective Center offers class A space with on-site amenities that no other multi-tenant building in Birmingham can provide.

Key features

  • 247365 onsite security
  • Free covered parking (41000 SF)
  • Large floor plates (40000 SF) with 10 finished ceiling heights ideal for larger office users
  • Located in Unincorporated Jefferson County (no occupational tax)
  • Onsite amenities coffee shop cafeteria fitness center courtyards walking tails and meeting rooms
  • Redundant power building served by two power feeds and backup generator

Rental Details

  • Number of spaces 1
  • Total square feet available 45,610 SF
  • For Lease Contact for pricing
  • Space Types General Office
  • Date Updated May 16, 2026
Want more info on this listing?

Reach out to the broker for more info on lease terms and amenities

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For Lease 1 Space Available

Space Available

  • Space Type General Office
  • Lease Rate Contact for pricing
  • Total Space Available 45,610 SF
  • Attachments pdf opens in new window pdf opens in new window pdf opens in new window
  • Divisible Space 45,610 - 45,610 SF
  • Available Date Immediate
  • Renewal Option Yes
  • Sublease No
  • Build Type Full build out
broker
Joe Sandner IV

Colliers

broker
John Hennessy

Colliers

Contacts

broker
Joe Sandner IV

Colliers

broker
John Hennessy

Colliers

Building Details

  • For Lease Contact for pricing
  • Property Type Office - General Office
  • Building Class A
  • Year Built 2001
  • Date Updated May 16, 2026

Getting Around

  • Walk Score ®

    Car-Dependent (44)
  • Bike Score ®

    Somewhat Bikeable (24)
Powered by Walk Score ®

Location

  • City Birmingham, AL
  • Neighborhood Old Mountain Brook
  • Zip Code 35223
  • Market Birmingham

Points of Interest

Mountain Brook, AL Supercharger

0.87 miles

Chevron

1.11 miles

BP

1.44 miles

Texaco

2.23 miles

Tesla Supercharger

4.17 miles

ChargePoint

5.85 miles

North Parking Deck

1.58 miles

Track and Soccer Stadium Parking

1.90 miles

West Parking Deck

1.93 miles

Vulcan Trail

1.98 miles

Edgewood Parking Deck

2.23 miles

St. Vincent's Child Care Parking

2.41 miles

32-F

2.45 miles

St. Vincent's Associate Parking

2.45 miles

St. Vincent's Deck One Parking

2.47 miles

Enterprise

2.95 miles

Goo-Goo Express Wash

3.01 miles

Budget

3.07 miles

Etheridge Brothers Car Wash

3.71 miles

Mister Car Wash

4.68 miles

Dollar

5.37 miles

Goo Goo Express Car Wash

6.96 miles

Splash N Go Car Wash

7.72 miles

Raindrop

8.74 miles

Hickory Tavern

0.29 miles

Five Guys

0.35 miles

Moe's Southwest Grill

0.47 miles

Wendy's

0.54 miles

Brick & Tin

0.55 miles

Daniel George

0.58 miles

Davenport's Pizza Palace

0.59 miles

Dunkin' Donuts

0.64 miles

Over Easy

0.78 miles

Target

0.66 miles

GreenWise Market at Lane Parke

0.84 miles

Piggly Wiggly

1.14 miles

Whole Foods Market

1.38 miles

Publix

2.15 miles

Winn-Dixie

2.36 miles

Gordo's Mexican food

2.96 miles

Valley Avenue Plaza

2.96 miles

Belk

2.96 miles

The Compounding Shoppe

1.04 miles

HealthSouth Lakeshore Rehabilitation Hospital

1.11 miles

CVS Pharmacy

1.13 miles

Encompass Health Lakeshore Rehabilitation Hospital

1.21 miles

Homewood City Police Department

1.29 miles

Mountain Brook Fire Station #2

1.61 miles

Walgreens

1.68 miles

Vestavia Hills Fire Station Number 1

2.00 miles

Publix Pharmacy

2.14 miles

2801 Hwy 280 S Listing Summary

  • Office Space Available at 2801 Hwy 280 S

    Office space currently available at 2801 Hwy 280 S adds up to a total of 45,610 square feet across 1 listing(s). The largest individual space listed offers 45,610 square feet. Property use types available for lease at this property include: general office.

  • Learn More about 2801 Hwy 280 S

    2801 Hwy 280 S is located in the Birmingham market and pertains to the 35223 zip code. The property incorporates a total of 45,610 square feet of space. 2801 Hwy 280 S was built in 2001.

    Interested in researching more about this property? Access in-depth research on 2801 Hwy 280 S, including ownership details, transaction history, property characteristics, taxes, mortgage data, violations and more by creating a free account and viewing the full property report.

  • Get to Know the Neighborhood

    In the Old Mountain Brook neighborhood, where 2801 Hwy 280 S is located, you can currently find 13 office space(s) for rent. In total, this amounts to 89,168 square feet of available office space for lease opportunities.

Contact Protective Center
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