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  1. Office Space
  2. CA
  3. San Francisco

Full Floor Creative Office Space

For Lease 1,600 SF

163 Second Street, San Francisco, CA 94105

163 Second Street a beautiful brick building on the corner of Second and Natoma Street located in the heart of the South Financial District. Second Street is the main thoroughfare from Caltrain and BART, as well as easy access to Muni and the Bay Bridge. Nearby amenities within walking distance include many great restaurants, bars, Transbay Terminal and Salesforce Park.163 Second Street is offering a full floor office space available for lease.

Key features

  • Efficient open floor plan
  • Elevator access
  • Entire 3rd Floor
  • Exposed brick
  • Large dedicated storage in basement
  • One (1) conference room
  • One (1) dedicated restroom
  • One (1) private office
  • Open kitchenette
  • Operable windows
  • Professional space with creative features
  • Seismically retrofitted building
  • Two sides of natural light

Rental Details

  • Number of spaces 1
  • Total square feet available 1,600 SF
  • For Lease $45.00/SF/YR
  • Space Type General Office
  • Lease Type Modified Gross
  • Latest Update Jul 23, 2026
View Attachment
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True

1 Space Available

Space Name Space Type Lease Rate Total Space Floor Lease Type Expand
Suite 300 General Office $45.00/SF/YR 1,600 SF 3 Modified Gross

Suite 300

Space Type

General Office

Lease Rate

$45.00/SF/YR

Additional Rent

Price on request

Total Space Available

1,600 SF

Floor

3

Divisible Space

1,600 - 1,600 SF

Available Date

Immediate

Lease Type

Modified Gross

Renewal Option

Yes

Sublease

No

Entire 3rd Floor Professional space with creative features Exposed brick One (1) conference room One (1) private office One (1) dedicated restroom Efficient floor plan Open kitchenette Two sides of natural light Elevator access

Suite 300

Space Type
General Office
Lease Rate
$45.00/SF/YR
Total Space
1,600 SF
Floor
3
Lease Type
Modified Gross
Space Type

General Office

Lease Rate

$45.00/SF/YR

Additional Rent

Price on request

Total Space Available

1,600 SF

Floor

3

Divisible Space

1,600 - 1,600 SF

Available Date

Immediate

Lease Type

Modified Gross

Renewal Option

Yes

Sublease

No

Entire 3rd Floor Professional space with creative features Exposed brick One (1) conference room One (1) private office One (1) dedicated restroom Efficient floor plan Open kitchenette Two sides of natural light Elevator access

Contacts

broker
Jerry Adamson

Ground Matrix

Building Details

  • For Lease $45.00/SF/YR
  • Property Type Office - General Office
  • Property Size 7,500 SF
  • Additional Rent Price on request
  • Building Class B
  • Date Updated Jul 23, 2026

Location

  • City San Francisco, CA
  • Neighborhood Yerba Buena
  • Zip Code 94105
  • Market San Francisco
  • Map
  • Street
  • Walk score 98/100 Walker's Paradise
  • Transit score 100/100 Rider's Paradise
  • Bike score 80/100 Very Bikeable
Powered by Walk Score ®

Points of Interest

Taxi Stand at Courtyard by Marriot SF Downtown

0.14 miles

Taxi Stand at Salesforce Transit Center

0.15 miles

Taxi Stand at W San Francisco (along Howard St)

0.18 miles

Taxi Stand at Palace Hotel

0.19 miles

Market Street (500 Block)

0.19 miles

Market Street & 2nd Street

0.20 miles

Market Street & New Montgomery Street

0.21 miles

Moscone Center

0.21 miles

Market Street & Montgomery Street

0.21 miles

Market Street & Sutter Street

0.21 miles

Shell

0.52 miles

Chevron

0.77 miles

EVgo

1.08 miles

Standard

1.32 miles

Volta HQ Charging Station

1.34 miles

76

1.55 miles

Tesla Destination Charger

1.66 miles

Arco

1.76 miles

Electrify America

1.80 miles

Rivian Waypoints

2.05 miles

SFMOMA Garage

0.11 miles

Palace Garage

0.14 miles

Moscone Center Garage

0.19 miles

Jessie Square Garage

0.27 miles

Four Seasons Valet Parking Entrance

0.30 miles

Marriott Valet Parking Entrance

0.33 miles

The White House Garage

0.35 miles

City Park

0.39 miles

5th and Mission Garage

0.44 miles

Sutter Stockton Garage

0.46 miles

Alamo/Enterprise/National

0.24 miles

Avis

0.40 miles

Budget

0.40 miles

Getaround

0.47 miles

City Car Share

0.47 miles

Zipcar

0.48 miles

Hertz

0.62 miles

Alamo

0.63 miles

National & Alamo

0.63 miles

Enterprise

0.65 miles

Lao Table

0.01 miles

Sweet greens

0.01 miles

Pie Punks

0.01 miles

North India

0.04 miles

Henry's Hunan Restaurant

0.05 miles

The Bird

0.08 miles

Trou Normand

0.08 miles

Tycoon Kitchen

0.08 miles

Mourad

0.08 miles

Luke’s Lobster

0.09 miles

Chaat Corner Indian Grocery

0.27 miles

Crocker Galleria

0.28 miles

Metreon

0.32 miles

Target

0.34 miles

Neiman Marcus

0.38 miles

Woodlands Market

0.38 miles

Ross

0.39 miles

Trader Joe's

0.40 miles

Whole Foods Market

0.44 miles

Bloomingdale's

0.46 miles

Care Essentials

0.03 miles

Walgreens

0.19 miles

Spring Fertility

0.26 miles

Security Office

0.34 miles

San Francisco VA Medical Center - Downtown Clinic

0.35 miles

Seafarers’ Medical Center

0.38 miles

South of Market Mental Health Center

0.40 miles

Focus Clinic

0.40 miles

Concentra Urgent Care

0.45 miles

Four-Fifty Sutter Pharmacy

0.51 miles

Listing Summary

  • Office Space Available at 163 Second Street

    Office space currently available at 163 Second Street adds up to a total of 1,600 square feet across 1 listing(s). The largest individual space listed offers 1,600 square feet. Property use types available for lease at this property include: general office.

  • Learn More about 163 Second Street

    163 Second Street is located in the San Francisco market and pertains to the 94105 zip code. The property incorporates a total of 1,600 square feet of space.

    Interested in researching more about this property? Access in-depth research on 163 Second Street, including ownership details, transaction history, property characteristics, taxes, mortgage data, violations and more by creating a free account and viewing the full property report.

  • Get to Know the Neighborhood

    In the Yerba Buena neighborhood, where 163 Second Street is located, you can currently find 414 office space(s) for rent. In total, this amounts to 5,961,088 square feet of available office space for lease opportunities.

Contact Jerry Adamson
broker
Jerry Adamson

Ground Matrix

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