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  1. Office Space
  2. CA
  3. San Francisco
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For Lease

Full Floor Creative Office Space

163 Second Street, San Francisco, CA 94105

1,600

SF Available
163 Second Street a beautiful brick building on the corner of Second and Natoma Street located in the heart of the South Financial District. Second Street is the main thoroughfare from Caltrain and BART, as well as easy access to Muni and the Bay Bridge. Nearby amenities within walking distance include many great restaurants, bars, Transbay Terminal and Salesforce Park.163 Second Street is offering a full floor office space available for lease.

Key features

  • Efficient open floor plan
  • Elevator access
  • Entire 3rd Floor
  • Exposed brick
  • Large dedicated storage in basement
  • One (1) conference room
  • One (1) dedicated restroom
  • One (1) private office
  • Open kitchenette
  • Operable windows
  • Professional space with creative features
  • Seismically retrofitted building
  • Two sides of natural light

Rental Details

  • Number of spaces 1
  • Total square feet available 1,600 SF
  • For Lease $45.00/SF/YR
  • Space Types General Office
  • Lease Type Modified Gross
  • Date Updated May 7, 2026
Want more info on this listing?

Reach out to the broker for more info on lease terms and amenities

True

For Lease 1 Space Available

Suite 300

  • Space Type General Office
  • Lease Rate $45.00/SF/YR
  • Total Space Available 1,600 SF
  • Floor 3
  • Divisible Space 1,600 - 1,600 SF
  • Available Date Immediate
  • Lease Type Modified Gross
  • Renewal Option Yes
  • Sublease No

Entire 3rd Floor Professional space with creative features Exposed brick One (1) conference room One (1) private office One (1) dedicated restroom Efficient floor plan Open kitchenette Two sides of natural light Elevator access

broker
Jerry Adamson

Ground Matrix

Contacts

broker
Jerry Adamson

Ground Matrix

Building Details

  • For Lease $45.00/SF/YR
  • Property Type Office - General Office
  • Property Size 7,500 SF
  • Building Class B
  • Date Updated May 7, 2026

Attachments

  • Property Brochure 1 ()opens in new window

Getting Around

  • Walk Score ®

    Walker's Paradise (98)
  • Transit Score ®

    Rider's Paradise (100)
  • Bike Score ®

    Very Bikeable (80)
Powered by Walk Score ®

Location

  • City San Francisco, CA
  • Neighborhood Yerba Buena
  • Zip Code 94105
  • Market San Francisco
  • Map
  • Street

Points of Interest

Taxi Stand at Salesforce Transit Center

0.15 miles

Taxi Stand at W San Francisco (along Howard St)

0.18 miles

Taxi Stand at Palace Hotel

0.19 miles

Market Street (500 Block)

0.19 miles

Market Street & 2nd Street

0.20 miles

Market Street & New Montgomery Street

0.21 miles

Moscone Center

0.21 miles

Market Street & Montgomery Street

0.21 miles

Market Street & Sutter Street

0.21 miles

Chevron

0.77 miles

EVgo

1.08 miles

Standard

1.32 miles

Volta HQ Charging Station

1.34 miles

76

1.55 miles

Tesla Destination Charger

1.66 miles

Arco

1.76 miles

Electrify America

1.80 miles

Rivian Waypoints

2.05 miles

Palace Garage

0.14 miles

Moscone Center Garage

0.19 miles

Jessie Square Garage

0.27 miles

Four Seasons Valet Parking Entrance

0.30 miles

Marriott Valet Parking Entrance

0.33 miles

The White House Garage

0.35 miles

City Park

0.39 miles

5th and Mission Garage

0.44 miles

Sutter Stockton Garage

0.46 miles

Avis

0.40 miles

Budget

0.40 miles

Getaround

0.47 miles

City Car Share

0.47 miles

Zipcar

0.48 miles

Hertz

0.62 miles

Alamo

0.63 miles

National & Alamo

0.63 miles

Enterprise

0.65 miles

Sweet greens

0.01 miles

Pie Punks

0.01 miles

North India

0.04 miles

Henry's Hunan Restaurant

0.05 miles

The Bird

0.08 miles

Trou Normand

0.08 miles

Tycoon Kitchen

0.08 miles

Mourad

0.08 miles

Luke’s Lobster

0.09 miles

Crocker Galleria

0.28 miles

Metreon

0.32 miles

Target

0.34 miles

Neiman Marcus

0.38 miles

Woodlands Market

0.38 miles

Ross

0.39 miles

Trader Joe's

0.40 miles

Whole Foods Market

0.44 miles

Bloomingdale's

0.46 miles

Walgreens

0.19 miles

Spring Fertility

0.26 miles

Security Office

0.34 miles

San Francisco VA Medical Center - Downtown Clinic

0.35 miles

Seafarers’ Medical Center

0.38 miles

South of Market Mental Health Center

0.40 miles

Focus Clinic

0.40 miles

Concentra Urgent Care

0.45 miles

Four-Fifty Sutter Pharmacy

0.51 miles

163 Second Street Listing Summary

  • Office Space Available at 163 Second Street

    Office space currently available at 163 Second Street adds up to a total of 1,600 square feet across 1 listing(s). The largest individual space listed offers 1,600 square feet. Property use types available for lease at this property include: general office.

  • Learn More about 163 Second Street

    163 Second Street is located in the San Francisco market and pertains to the 94105 zip code. The property incorporates a total of 1,600 square feet of space.

    Interested in researching more about this property? Access in-depth research on 163 Second Street, including ownership details, transaction history, property characteristics, taxes, mortgage data, violations and more by creating a free account and viewing the full property report.

  • Get to Know the Neighborhood

    In the Yerba Buena neighborhood, where 163 Second Street is located, you can currently find 415 office space(s) for rent. In total, this amounts to 5,990,268 square feet of available office space for lease opportunities.

Contact Listing Broker
broker
Jerry Adamson

Ground Matrix

  1. 1Main information
  2. 2Extra information
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