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South San Francisco, CA Office Spaces for Rent - 120 Spaces

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  • Airport Boulevard - South San Francisco

    Airport Boulevard

    11 Airport Blvd, Lindenville, South San Francisco, CA
    For Lease
    • Contact for pricing
    Property
    • Office
    • 52,327 Sqft
    Availability
    • 2 Spaces
    • 3,900 Sqft
    Year Built
    • 1987
    View Details
  • 701 Gateway - S San Francisco

    701 Gateway

    701 Gateway Blvd, Gateway, S San Francisco, CA
    For Lease
    • $39/Sqft/Year
    Property
    • Office
    • 176,036 Sqft
    Availability
    • 1 Space
    • 4,293 Sqft
    Year Built
    • 1999
    View Details
  • 7000 Shoreline Court - South San Francisco

    7000 Shoreline Court

    7000 Shoreline Court, Paradise Valley, South San Francisco, CA
    For Lease
    • $84/Sqft/Year
    Property
    • Office
    • 136,395 Sqft
    Availability
    • 3 Spaces
    • 35,435 Sqft
    Year Built
    • 2003
    View Details
  • The Gateway Technology Center - 600 Gateway Blvd - South San Francisco

    The Gateway Technology Center - 600 Gateway Blvd

    600 Gateway Blvd, The East Side, South San Francisco, CA
    For Lease
    • $5.75/Sqft/Month
    Property
    • Office
    • 81,308 Sqft
    Availability
    • 2 Spaces
    • 14,000 Sqft
    Year Built
    • 1998
    View Details
  • Oyster Point Marina Plaza II - S San Francisco

    Oyster Point Marina Plaza II

    395 Oyster Point Blvd, Oyster Point, S San Francisco, CA
    For Lease
    • Contact for pricing
    Property
    • Office
    • 232,733 Sqft
    Availability
    • 17 Spaces
    • 104,064 Sqft
    Year Built
    • 1986
    View Details
  • 90 South Spruce - S San Francisco

    90 South Spruce

    90 Spruce Ave, S., Orange Park, S San Francisco, CA
    For Lease
    • $25.8 - $33/Sqft/Year
    Property
    • Industrial
    • 36,410 Sqft
    Availability
    • 4 Spaces
    • 5,202 Sqft
    Year Built
    • 1900
    View Details
  • Genesis - North Tower - South San Francisco

    Genesis - North Tower

    2 Tower Place, Paradise Valley, South San Francisco, CA
    For Lease
    • $69/Sqft/Year
    Property
    • Office
    • 381,523 Sqft
    Availability
    • 3 Spaces
    • 34,267 Sqft
    Year Built
    • 2018
    View Details
  • 405 Victory Avenue - South San Francisco

    405 Victory Avenue

    405 Victory Avenue, Lindenville, South San Francisco, CA
    For Lease
    • $16.2 - $18.6/Sqft/Year
    Property
    • Industrial
    • 211,259 Sqft
    Availability
    • 6 Spaces
    • 129,208 Sqft
    Year Built
    • 1958
    View Details
  • 221-231 Michelle Ct - S San Francisco

    221-231 Michelle Ct

    221-231 Michelle Ct, The East Side, S San Francisco, CA
    For Lease
    • $17.4/Sqft/Year
    Property
    • Industrial
    • 30,000 Sqft
    Availability
    • 1 Space
    • 15,000 Sqft
    View Details
  • Oyster Point Marina Plaza I - S San Francisco

    Oyster Point Marina Plaza I

    400 Oyster Point Blvd, Oyster Point, S San Francisco, CA
    For Lease
    • $40.8 - $42/Sqft/Year
    Property
    • Office
    • 231,769 Sqft
    Availability
    • 19 Spaces
    • 34,347 Sqft
    Year Built
    • 1986
    View Details
  • 100-130 Produce Avenue - South San Francisco

    100-130 Produce Avenue

    100 Produce Avenue, Lindenville, South San Francisco, CA
    For Lease
    • $0.8 - $1.5/Sqft/Month
    Property
    • Office
    • 41,448 Sqft
    Availability
    • 2 Spaces
    • 3,917 Sqft
    Year Built
    • 1986
    View Details
  • 400 Oyster Point Blvd - South San Francisco

    400 Oyster Point Blvd

    400 Oyster Point Blvd, Oyster Point, South San Francisco, CA
    For Lease
    • $2.75/Sqft/Month
    Property
    • Office
    • 234,480 Sqft
    Availability
    • 1 Space
    • 2,314 Sqft
    Year Built
    • 1985
    View Details
  • The Gateway North Campus - 701 Gateway Blvd - South San Francisco

    The Gateway North Campus - 701 Gateway Blvd

    701 Gateway Blvd, Gateway, South San Francisco, CA
    For Lease
    • $54/Sqft/Year
    Property
    • Office
    • 170,323 Sqft
    Availability
    • 2 Spaces
    • 13,705 Sqft
    Year Built
    • 1999
    View Details
  • The Gateway Technology Center - 630 Gateway Blvd - South San Francisco

    The Gateway Technology Center - 630 Gateway Blvd

    630 Gateway Blvd, The East Side, South San Francisco, CA
    For Lease
    • $66/Sqft/Year
    Property
    • Office
    • 50,160 Sqft
    Availability
    • 1 Space
    • 61,160 Sqft
    Year Built
    • 2001
    View Details
  • The Gateway North Campus - 951 Gateway Blvd - South San Francisco

    The Gateway North Campus - 951 Gateway Blvd

    951 Gateway Blvd, Gateway, South San Francisco, CA
    For Lease
    • Contact for pricing
    Property
    • Office
    • 59,816 Sqft
    Availability
    • 2 Spaces
    • 39,000 Sqft
    Year Built
    • 2002
    View Details
  • Gateway Crossing - 1 Corporate Drive - South San Francisco

    Gateway Crossing - 1 Corporate Drive

    1 Corporate Drive, Gateway, South San Francisco, CA
    For Lease
    • Contact for pricing
    Property
    • Office
    • 71,479 Sqft
    Availability
    • 1 Space
    • 36,000 Sqft
    Year Built
    • 1999
    View Details

Office Space Listings Overview

There’s a total of 38 office listings available for rent in South San Francisco, CA. Across 120 unique spaces, there is a grand total of 2,280,237 square feet. The variety of Office spaces range from 667 square feet to 900,000 square feet. You can also filter your search by location, price, available space, asking price and more, making it easy to select what works best for you or your business.

Find Office Space Near Me

Trying to find the right office space near you that meets all your business needs? PropertyShark lets you browse tons of available office spaces in your area, making finding the right home for your company easy. Sizes, amenities, prices and locations of office spaces for rent are all available to be browsed with just a click. You can also step outside of your current city and explore new ones — even reach out to brokers to learn more about the space and the surrounding area. Find your ideal office space for rent near South San Francisco, CA with just a simple search.

South San Francisco, CA Office Inventory Breakdown

Office Spaces

Total: 22,311,760 SF

Data provided by Yardi Matrix, properties over 50k SF, includes office with retail
By square footage range:
50k to 100k SqFt 1,961,746 SqFt 8.79% of total office
100k to 500k SqFt 12,773,523 SqFt 57.25% of total office
500k to 1M SqFt 6,168,130 SqFt 27.65% of total office
> 1M SqFt 1,408,361 SqFt 6.31% of total office
By class:
Class A 12,798,788 SqFt 57.36% of total office
Class B 3,944,380 SqFt 17.68% of total office

Top 10 Largest Office Buildings

in South San Francisco

Office building Address Sqft Year built
Genentech Headquarters - Lower Main Campus 1 DNA Way, 94080 1,408,361 1970
Inception 379 Oyster Point Blvd, 94080 656,000 2021
Britannia Pointe Grand 250 East Grand Avenue, 94080 630,500 1989
Gateway of Pacific I 1000 Gateway Blvd, 94080 509,000 2021
Gateway of Pacific II 750 Gateway Blvd, 94080 440,000 2021
Genesis - North Tower 2 Tower Place, 94080 381,523 2018
201 Haskins Way 201 Haskins Way, 94080 311,368 2021
The Merck Campus 221 East Grand Avenue, 94080 294,000 2019
Gateway Commons - 651 Gateway 651 Gateway Blvd, 94080 290,448 1986
Genentech Headquarters - Mid Main Campus - Buildings 13-15 340 Point San Bruno Blvd, 94080 277,814 2003

Largest Office Properties Recently Completed

in South San Francisco

Office building Address Sqft Year built
Inception 379 Oyster Point Blvd, 94080 656,000 2021
Gateway of Pacific I 1000 Gateway Blvd, 94080 509,000 2021
Gateway of Pacific II 750 Gateway Blvd, 94080 440,000 2021
201 Haskins Way 201 Haskins Way, 94080 311,368 2021
The Cove at Oyster Point V 181 Oyster Point Blvd, 94080 164,150 2020
The Merck Campus 221 East Grand Avenue, 94080 294,000 2019
279 East Grand Avenue 279 East Grand Avenue, 94080 211,405 2019
The Cove at Oyster Point VII 131 Oyster Point Blvd, 94080 175,830 2019
Britannia East Grand: Genentech Headquarters - South Campus - Building 40 500 East Grand Avenue, 94080 160,582 2019
The Cove at Oyster Point VI 161 Oyster Point Blvd, 94080 148,020 2019

Frequently Asked Questions

What is the cost of renting an office space in South San Francisco, CA?

The average rental rate for an office space currently rests at $59.72 per square foot. Check all office space listings with a similar average rental rate.

What is the average size of office spaces available in South San Francisco, CA?

Presently, the average size of office space availabilities is roughly 450,334 square feet. The largest rentable office space in South San Francisco is 900,000 square feet, with the minimum at 667 square feet. Check all available office spaces.

How to rent office space in South San Francisco, CA ?

Before you begin your office space hunt, there are a couple of things you need to consider. For instance, deciding how much office space you’ll need and whether you prefer a specific location within the city can help you focus in on the listings that truly fit your business requirements. We recommend you contact the listed broker(s) for each property page that makes it unto your shortlist for more in-depth information and to schedule a viewing.

Which South San Francisco, CA neighborhoods are popular to rent office space in?

Most popular South San Francisco neighbourhoods with office spaces availabilities on PropertyShark include The East Side, Oyster Point and Lindenville.

What property types are available for rent in South San Francisco, CA?

Commercial real estate availabilities listed on our platform include everything from industrial properties to retail spaces, as well as coworking offices and traditional office spaces for rent in South San Francisco, CA.

How many office space listings are available in South San Francisco, CA?

There is a total of 120 office space listings available for rent in South San Francisco, CA. See South San Francisco office spaces for rent, or check all available commercial real estate listings.