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South San Francisco, CA Office Spaces for Rent - 98 Spaces

  • 7000 Shoreline Court - South San Francisco
    7000 Shoreline Court, Paradise Valley, South San Francisco, CA
    For Lease
    • $84/Sqft/Year
    Property
    • Office
    • 136,395 Sqft
    Availability
    • 3 Spaces
    • 39,430 Sqft
    Year Built
    • 2003
    View Details
  • 701 Gateway - S San Francisco
    701 Gateway Blvd, Gateway, S San Francisco, CA
    For Lease
    • $39/Sqft/Year
    Property
    • Office
    • 176,036 Sqft
    Availability
    • 1 Space
    • 4,293 Sqft
    Year Built
    • 1999
    View Details
  • Oyster Point Marina Plaza II - S San Francisco
    395 Oyster Point Blvd, Oyster Point, S San Francisco, CA
    For Lease
    • Contact for pricing
    Property
    • Office
    • 232,733 Sqft
    Availability
    • 17 Spaces
    • 95,275 Sqft
    Year Built
    • 1986
    View Details
  • The Gateway Technology Center - 600 Gateway Blvd - South San Francisco
    600 Gateway Blvd, The East Side, South San Francisco, CA
    For Lease
    • $5.75/Sqft/Month
    Property
    • Office
    • 81,308 Sqft
    Availability
    • 2 Spaces
    • 14,000 Sqft
    Year Built
    • 1998
    View Details
  • Gateway Commons - S San Francisco
    611 Gateway Blvd, Gateway, S San Francisco, CA
    For Lease
    • $45/Sqft/Year
    Property
    • Office
    • 260,337 Sqft
    Availability
    • 1 Space
    • 13,943 Sqft
    Year Built
    • 2002
    View Details
  • 701 Gateway - South San Francisco
    701 Gateway Blvd, Gateway, South San Francisco, CA
    For Lease
    • $4.5/Sqft/Month
    Property
    • Office
    • 170,323 Sqft
    Availability
    • 1 Space
    • 9,655 Sqft
    Year Built
    • 1999
    View Details
  • 90 South Spruce - S San Francisco
    90 Spruce Ave, S., Orange Park, S San Francisco, CA
    For Lease
    • $25.8 - $33/Sqft/Year
    Property
    • Industrial
    • 36,410 Sqft
    Availability
    • 4 Spaces
    • 5,202 Sqft
    Year Built
    • 1900
    View Details
  • Genesis - North Tower - South San Francisco
    2 Tower Place, Paradise Valley, South San Francisco, CA
    For Lease
    • $69/Sqft/Year
    Property
    • Office
    • 381,523 Sqft
    Availability
    • 3 Spaces
    • 34,267 Sqft
    Year Built
    • 2018
    View Details
  • The Gateway Technology Center - 630 Gateway Blvd - South San Francisco
    630 Gateway Blvd, The East Side, South San Francisco, CA
    For Lease
    • $66/Sqft/Year
    Property
    • Office
    • 50,160 Sqft
    Availability
    • 1 Space
    • 50,160 Sqft
    Year Built
    • 2001
    View Details
  • 601 Gateway - South San Francisco
    601 Gateway Blvd, Gateway, South San Francisco, CA
    For Lease
    • $48/Sqft/Year
    Property
    • Office
    • 215,832 Sqft
    Availability
    • 1 Space
    • 4,987 Sqft
    Year Built
    • 1984
    View Details
  • The Gateway Technology Center - 650 Gateway Blvd - South San Francisco
    650 Gateway Blvd, The East Side, South San Francisco, CA
    For Lease
    • $66/Sqft/Year
    Property
    • Office
    • 50,400 Sqft
    Availability
    • 1 Space
    • 50,400 Sqft
    Year Built
    • 1999
    View Details
  • 100-130 Produce Avenue - South San Francisco
    100 Produce Avenue, Lindenville, South San Francisco, CA
    For Lease
    • $9.6 - $19.5/Sqft/Year
    Property
    • Office
    • 41,448 Sqft
    Availability
    • 2 Spaces
    • 3,917 Sqft
    Year Built
    • 1986
    View Details
  • 405 Victory Avenue - South San Francisco
    405 Victory Avenue, Lindenville, South San Francisco, CA
    For Lease
    • $16.2 - $18.6/Sqft/Year
    Property
    • Industrial
    • 211,259 Sqft
    Availability
    • 6 Spaces
    • 129,208 Sqft
    Year Built
    • 1958
    View Details
  • 400 Oyster Point Blvd - South San Francisco
    400 Oyster Point Blvd, Oyster Point, South San Francisco, CA
    For Lease
    • $33/Sqft/Year
    Property
    • Office
    • 234,480 Sqft
    Availability
    • 1 Space
    • 2,314 Sqft
    Year Built
    • 1985
    View Details
  • 2400 Westborough Blvd - South San Francisco
    2400 Westborough Blvd, North Westborough, South San Francisco, CA
    For Lease
    • $2.75/Sqft/Month
    Property
    • Office
    • 32,214 Sqft
    Availability
    • 1 Space
    • 1,011 Sqft
    Year Built
    • 1976
    View Details
  • Oyster Point Marina Plaza I - S San Francisco
    400 Oyster Point Blvd, Oyster Point, S San Francisco, CA
    For Lease
    • $40.8 - $42/Sqft/Year
    Property
    • Office
    • 231,769 Sqft
    Availability
    • 18 Spaces
    • 30,074 Sqft
    Year Built
    • 1986
    View Details

Office Space Listings Overview

There’s a total of 38 office listings available for rent in South San Francisco, CA. Across 98 unique spaces, there is a grand total of 1,263,953 square feet. The variety of spaces range from 225 square feet to 350,000 square feet. You can also filter your search by location, price, available space, asking price and more, making it easy to select what works best for you or your business.

South San Francisco, CA Commercial Inventory Breakdown

Office Spaces

Total: 20,073,561 SF

Data provided by Yardi Matrix, properties over 50k SF, includes office with retail

By square footage range:

  • 50k to 100k SF: 1,961,746 SF / 9.77% of total office
  • 100k to 500k SF: 12,763,824 SF / 63.59% of total office
  • 500k to 1M SF: 3,939,630 SF / 19.63% of total office
  • > 1M SF: 1,408,361 SF / 7.02% of total office

By class:

  • Class A: 11,083,552 SF / 55.21% of total office
  • Class B: 3,944,380 SF / 19.65% of total office

Top 10 Largest Office Buildings

in South San Francisco

Office building Address Sqft Year built
Genentech Headquarters - Lower Main Campus 1 DNA Way, 94080 1,408,361 1970
Kilroy Oyster Point - Phase I 379 Oyster Point Blvd, 94080 656,000 2021
Gateway of Pacific I 1000 Gateway Blvd, 94080 510,000 2021
Gateway of Pacific II 750 Gateway Blvd, 94080 440,000 2021
Genesis - North Tower 2 Tower Place, 94080 381,523 2018
Gateway of Pacific III 700 Gateway Blvd, 94080 360,000 2021
201 Haskins Way 201 Haskins Way, 94080 311,369 2021
The Merck Campus 221 East Grand Avenue, 94080 294,000 2019
Genentech Headquarters - Mid Main Campus - Buildings 13-15 340 Point San Bruno Blvd, 94080 277,814 2003
Genentech Headquarters - Mid Main Campus - Buildings 10-12 & 36 99 DNA Way, 94080 276,044 1975

Largest Office Properties Recently Completed

in South San Francisco

Office building Address Sqft Year built
Kilroy Oyster Point - Phase I 379 Oyster Point Blvd, 94080 656,000 2021
Gateway of Pacific I 1000 Gateway Blvd, 94080 510,000 2021
Gateway of Pacific II 750 Gateway Blvd, 94080 440,000 2021
Gateway of Pacific III 700 Gateway Blvd, 94080 360,000 2021
201 Haskins Way 201 Haskins Way, 94080 311,369 2021
The Cove at Oyster Point V 181 Oyster Point Blvd, 94080 164,150 2020
The Merck Campus 221 East Grand Avenue, 94080 294,000 2019
279 East Grand Avenue 279 East Grand Avenue, 94080 211,405 2019
The Cove at Oyster Point VII 131 Oyster Point Blvd, 94080 175,830 2019
Britannia East Grand: Genentech Headquarters - South Campus - Building 40 500 East Grand Avenue, 94080 160,582 2019

Frequently Asked Questions

What is the cost of renting an office space in South San Francisco, CA?

The average rental rate for an office space currently rests at $41.65 per square foot. Check all office space listings with a similar average rental rate.

What is the average size of office spaces available in South San Francisco, CA?

Presently, the average size of office space availabilities is roughly 175,113 square feet. The largest rentable office space in South San Francisco is 350,000 square feet, with the minimum at 225 square feet. Check all available office spaces.

How to rent office space in South San Francisco, CA ?

Before you begin your office space hunt, there are a couple of things you need to consider. For instance, deciding how much office space you’ll need and whether you prefer a specific location within the city can help you focus in on the listings that truly fit your business requirements. We recommend you contact the listed broker(s) for each property page that makes it unto your shortlist for more in-depth information and to schedule a viewing.

Which South San Francisco, CA neighborhoods are popular to rent office space in?

Most popular South San Francisco neighbourhoods with office spaces availabilities on PropertyShark include The East Side, Gateway and Oyster Point.

What property types are available for rent in South San Francisco, CA?

Commercial real estate availabilities listed on our platform include everything from industrial properties to retail spaces, as well as coworking offices and traditional office spaces for rent in South San Francisco, CA.

How many office space listings are available in South San Francisco, CA?

There is a total of 98 office space listings available for rent in South San Francisco, CA. See South San Francisco office spaces for rent, or check all available commercial real estate listings.