South San Francisco, CA Office Space

Search office properties for lease and view the Market Overview section below for local stats and insight.

194 Listings

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From $848/month
Spaces - South San Francisco - Spaces Oyster Point
611 Gateway Boulevard #120, South San Francisco, CA
Space Type
Private Offices
Space for 1 to 15 people
1 of 4

2 of 4

3 of 4

4 of 4
$0.60/SF/MO
Gateway of Pacific V - South Building
485 Eccles Avenue, The East Side, South San Francisco, CA
Space Type
Office
4 spaces

33,500 - 38,200 SF
1 of 4

2 of 4

3 of 4

4 of 4
Price on request
343 Oyster Point Blvd
343 Oyster Point Blvd, Oyster Point, South San Francisco, CA
Space Type
Office
3 spaces

4,511 - 17,507 SF
1 of 4

2 of 4

3 of 4

4 of 4
Price on request
Britannia Oyster Point I - C
1140 Veterans Blvd, Oyster Point, South San Francisco, CA
Space Type
Office
2 spaces

26,953 - 27,155 SF
Narrow down your search by listing type
1 of 3

2 of 3

3 of 3
Price on request
Genesis - North Tower
2 Tower Place, Paradise Valley, South San Francisco, CA
Space Type
Office
5 spaces

11,480 - 19,986 SF
1 of 4

2 of 4

3 of 4

4 of 4
Price on request
Britannia Oyster Point II - Building A
333 Oyster Point Blvd, Oyster Point, South San Francisco, CA
Space Type
Office
5 spaces

30,140 - 32,169 SF
1 of 4

2 of 4

3 of 4

4 of 4
Price on request
The Cove at Oyster Point I
111 Oyster Point Blvd, Oyster Point, South San Francisco, CA
Space Type
Office
1 space

29,711 SF
1 of 3

2 of 3

3 of 3
Price on request
201 Haskins Way
201 Haskins Way, The East Side, South San Francisco, CA
Space Type
Office
2 spaces

15,212 - 25,471 SF
1 of 5

2 of 5

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5 of 5
Price on request
Gateway Commons - 601 Gateway
601 Gateway Blvd, Gateway, South San Francisco, CA
Space Type
Office
16 spaces

1,744 - 19,139 SF
1 of 5

2 of 5

3 of 5

4 of 5

5 of 5
$2.95/SF/YR
Edgewater Science Park
260 Littlefield Avenue, The East Side, South San Francisco, CA
Space Type
Office
3 spaces

8,294 - 14,943 SF
1 of 6

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Price on request
5000 Shoreline Court
5000 Shoreline Court, Paradise Valley, South San Francisco, CA
Space Type
Office
2 spaces

21,103 - 25,977 SF
1 of 3

2 of 3

3 of 3
$60.00/SF/YR
Genesis North Tower
2 Tower Place, Paradise Valley, S San Francisco, CA
Space Type
Office
3 spaces

19,482 SF
1 of 5

2 of 5

3 of 5

4 of 5

5 of 5
Price on request
Alexandria Center for Science and Technology at Mission Bay - 400 East Jamie Court
400 East Jamie Court, The East Side, South San Francisco, CA
Space Type
Office
1 space

30,491 SF
1 of 4

2 of 4

3 of 4

4 of 4
Price on request
The Gateway Technology Center - 630 Gateway Blvd
630 Gateway Blvd, The East Side, South San Francisco, CA
Space Type
Office
1 space

23,692 SF
1 of 4

2 of 4

3 of 4

4 of 4
Price on request
Kilroy Oyster Point - II
373 Oyster Point Blvd, Oyster Point, San Francisco, CA
Space Type
Office
21 spaces

43,500 SF
1 of 4

2 of 4

3 of 4

4 of 4
Price on request
7000 Shoreline Court
7000 Shoreline Court, Paradise Valley, South San Francisco, CA
Space Type
Office
4 spaces

3,402 - 29,162 SF
1 of 3

2 of 3

3 of 3
Price on request
Gateway of Pacific II
750 Gateway Blvd, The East Side, South San Francisco, CA
Space Type
Office
3 spaces

12,000 - 25,500 SF
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Price on request
Gateway Crossing - 2 Corporate Drive
2 Corporate Drive, Gateway, South San Francisco, CA
Space Type
Office
1 space

45,912 SF
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Price on request
Britannia Modular Labs I
285 East Grand Avenue, The East Side, South San Francisco, CA
Space Type
Office
6 spaces

7,000 - 33,161 SF
1 of 4

2 of 4

3 of 4

4 of 4
Price on request
The Gateway Technology Center - 600 Gateway Blvd
600 Gateway Blvd, The East Side, South San Francisco, CA
Space Type
Office
4 spaces

4,285 - 13,579 SF
1 of 4

2 of 4

3 of 4

4 of 4
Price on request
The Cove at Oyster Point III
151 Oyster Point Blvd, Oyster Point, South San Francisco, CA
Space Type
Office
2 spaces

38,086 - 38,087 SF
1 of 4

2 of 4

3 of 4

4 of 4
Price on request
The Cove at Oyster Point VII
131 Oyster Point Blvd, Oyster Point, South San Francisco, CA
Space Type
Office
3 spaces

34,988 - 38,087 SF
1 of 4

2 of 4

3 of 4

4 of 4
Price on request
400 Oyster Point Blvd
400 Oyster Point Blvd, Oyster Point, South San Francisco, CA
Space Type
Office
1 space

40,000 SF
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2 of 5

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5 of 5
Price on request
Britannia Pointe Grand
250 East Grand Avenue, The East Side, South San Francisco, CA
Space Type
Office
8 spaces

27,999 - 32,012 SF
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$2.00/SF/MO
Oyster Point Business Park
389 Oyster Point Blvd, Oyster Point, San Francisco, CA
Space Type
Office
1 space

3,329 SF
1 of 4

2 of 4

3 of 4

4 of 4
$0.08 - $0.12/SF/MO
Produce Avenue Business Park
100 Produce Avenue, Lindenville, South San Francisco, CA
Space Type
Office
2 spaces

1,950 - 1,967 SF
1 of 4

2 of 4

3 of 4

4 of 4
Price on request
Britannia Modular Labs IV
100 Kimball Way, The East Side, South San Francisco, CA
Space Type
Office
3 spaces

10,951 - 49,838 SF
1 of 3

2 of 3

3 of 3
Price on request
Gateway Commons - 651 Gateway
651 Gateway Blvd, Gateway, South San Francisco, CA
Space Type
Office
13 spaces

11,061 - 22,947 SF
1 of 4

2 of 4

3 of 4

4 of 4
Price on request
The Cove At Oyster Point 5
181 Oyster Point Blvd, Oyster Point, S San Francisco, CA
Space Type
Office
2 spaces

33,771 - 36,838 SF
1 of 5

2 of 5

3 of 5

4 of 5

5 of 5
Price on request
Gateway Commons - 611 Gateway
611 Gateway Blvd, Gateway, South San Francisco, CA
Space Type
Office
2 spaces

7,237 - 24,768 SF
1 of 4

2 of 4

3 of 4

4 of 4
Price on request
279 East Grand Avenue
279 East Grand Avenue, The East Side, South San Francisco, CA
Space Type
Office
1 space

35,234 SF
1 of 4

2 of 4

3 of 4

4 of 4
Price on request
The Gateway North Campus - 951 Gateway Blvd
951 Gateway Blvd, Gateway, South San Francisco, CA
Space Type
Office
2 spaces

8,250 - 21,827 SF
1 of 4

2 of 4

3 of 4

4 of 4
Price on request
Southline - Building 1
30 Tanforan Avenue, Lindenville, South San Francisco, CA
Space Type
Office
1 space

375,000 SF
1 of 4

2 of 4

3 of 4

4 of 4
Price on request
Britannia Oyster Point II - Building B
331 Oyster Point Blvd, Oyster Point, South San Francisco, CA
Space Type
Office
3 spaces

30,000 - 33,333 SF
1 of 4

2 of 4

3 of 4

4 of 4
$0.40/SF/MO
468 Littlefield Avenue
468 Littlefield Avenue, The East Side, South San Francisco, CA
Space Type
Office
1 space

44,311 SF
1 of 4

2 of 4

3 of 4

4 of 4
$0.60/SF/MO
Gateway of Pacific V - North Building
475 Eccles Avenue, The East Side, South San Francisco, CA
Space Type
Office
4 spaces

32,400 SF
1 of 5

2 of 5

3 of 5

4 of 5

5 of 5
Price on request
Alexandria Center for Science and Technology at Mission Bay - 450 East Jamie Court
450 East Jamie Court, The East Side, South San Francisco, CA
Space Type
Office
2 spaces

29,745 - 29,757 SF
1 of 6

2 of 6

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6 of 6
Price on request
The Gateway North Campus - 701 Gateway Blvd
701 Gateway Blvd, Gateway, South San Francisco, CA
Space Type
Office
11 spaces

1,521 - 29,470 SF
1 of 5

2 of 5

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5 of 5
Price on request
Gateway Crossing
611 Gateway Blvd, Gateway, S San Francisco, CA
Space Type
Office
1 space

3,469 SF
1 of 5

2 of 5

3 of 5

4 of 5

5 of 5
Price on request
Genesis - South Tower
1 Tower Place, Paradise Valley, South San Francisco, CA
Space Type
Office
2 spaces

14,674 - 31,500 SF

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Average Rent for Office Space in South San Francisco, CA

Rents for offices in South San Francisco range between $29.4 and $69 per square foot, with the market-wide average currently at $55.11 per square foot according to the latest listing data.

Learn More About Office Spaces for Rent in South San Francisco, CA

The South San Francisco, CA market currently features 194 distinct office spaces available for lease, totaling approximately 7.6 million square feet.

Local inventory includes subtypes such as Life Sciences with 108 listings, as well as other property types such as R&D - Office and General Office.

Available office spaces range from 742 square feet to 2,500,000 square feet, with an average size of 40,339 square feet, accommodating businesses across various growth stages and operational requirements.

Range Total Square Feet Share of Total Office

25k to 50k Sq. Ft. 377,366 2.07%

50k to 100k Sq. Ft. 2,205,304 12.12%

100k to 500k Sq. Ft. 11,542,792 63.44%

500k to 1M Sq. Ft. 2,660,500 14.62%

> 1M Sq. Ft. 1,408,361 7.74%

Of the office inventory in South San Francisco, 74 properties were constructed since 2000, typically offering up-to-date amenities. An additional 25 buildings were developed between 1975 and 2000, while the remaining 9 date prior to 1975.

South San Francisco, CA Office Property By Year Built

1

1900 - 1925

8

1950 - 1975

25

1975 - 2000

74

After 2000

South San Francisco, CA Office Market Breakdown

The office market in South San Francisco, CA comprises 61 buildings totaling 18.2 million square feet.

Class A and A+ properties make up 72.33% of the office market in South San Francisco, while Class B properties total 22.64% of the market and Class C properties take up the remaining 5.03%.

Range Total Square Feet Share of Total Office

Class A 14,305,422 78.63%

Class B 3,721,651 20.46%

Class C 167,250 0.92%

The market offers substantial flexibility in space configuration, with spaces reaching up to 2,500,000 square feet and an average square footage of 40,339 across all spaces located here.

Best Neighborhoods for Office Space in South San Francisco, CA

South San Francisco’s neighborhood with the most office spaces is The East Side, offering 62 listings currently available.

The neighborhoods with the next largest offerings include Gateway with 55 listings, as well as Oyster Point, which offers a total of 42 listings.

Neighborhood No. of Listings Total Sq. Ft.

The East Side 62 1,447,632

Gateway 55 1,000,306

Oyster Point 42 1,505,224

Paradise Valley 16 294,651

Lindenville 8 3,343,917