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Map of Property

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For Lease

OFFICE SPACE FOR LEASE

220 S Spruce Ave, South San Francisco, CA 94080

3,828

SF Available
510 Myrtle and 220 S Spruce are two buildings on one parcel.

Lease Note
3 private offices with bullpen.

Key features

  • Highway Access - 101, 280, 380
  • Public Transportation - Bart and CalTrain

Rental Details

  • Number of spaces 2
  • Total square feet available 3,828 SF
  • For Lease $2.25/SF/MO
  • Space Types General Office
  • Date Updated May 25, 2026
Want more info on this listing?

Reach out to the broker for more info on lease terms and amenities

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For Lease 2 Spaces Available

Suite 107

  • Space Type General Office
  • Lease Rate $2.25/SF/MO
  • Total Space Available 1,668 SF
  • Attachments pdf opens in new window
  • Floor 1
  • Divisible Space 1,668 - 1,668 SF
  • Available Date Immediate
  • Renewal Option Yes
  • Sublease No
  • Build Type Full build out
broker
Mike Davis

Colliers

Suite 204

  • Space Type General Office
  • Lease Rate $2.25/SF/MO
  • Total Space Available 2,160 SF
  • Attachments pdf opens in new window
  • Floor 2
  • Divisible Space 2,160 - 2,160 SF
  • Available Date Immediate
  • Renewal Option Yes
  • Sublease No
  • Build Type Full build out
broker
Mike Davis

Colliers

Contacts

broker
Mike Davis

Colliers

Building Details

  • For Lease $2.25/SF/MO
  • Property Type Office - General Office
  • Parking Ratio 4.00 / 1,000 SF
  • Building Class C
  • Year Built 1984
  • Date Updated May 25, 2026

Getting Around

  • Walk Score ®

    Very Walkable (77)
  • Bike Score ®

    Very Bikeable (86)
Powered by Walk Score ®

Location

  • City South San Francisco, CA
  • Neighborhood Orange Park
  • Zip Code 94080
  • Market San Francisco

Points of Interest

Long Term Parking

1.39 miles

South San Francisco

1.74 miles

West Field Road

2.13 miles

San Francisco International Airport

2.69 miles

San Francisco International Airport (SFO)

2.71 miles

Taxi Stand at International Arrivals SFO

2.75 miles

Taxi Stand at SFO, Domestic Terminal 3 (Arrivals Level in front of Door 5, 6, 7, 8, 9, 10)

2.76 miles

Terminal 3

2.78 miles

Taxi Stand at Grand Hyatt at SFO

2.81 miles

EVgo

0.72 miles

True Zero

0.74 miles

76

0.77 miles

Valero

0.77 miles

Chico's

0.79 miles

EV Range

0.91 miles

Speedway

1.00 miles

Golden Gate Gasoline

1.12 miles

Blink

1.37 miles

SFO Long-Term Parking Garage #1

1.32 miles

ParkSFO

1.36 miles

SFO Long-Term Parking

1.42 miles

SFO TNC Staging Lot 3

1.44 miles

Cell Phone Waiting Lot

1.46 miles

Charter Bus Staging Lot

1.46 miles

Taxi Staging Lot

1.48 miles

Worksite Labs Testing Site at SFO

1.50 miles

United Airlines East Parking Lot

1.66 miles

Fox Rent a Car

1.03 miles

G&S Truck Wash

1.04 miles

Airport Rent a Car

1.34 miles

Alamo

1.69 miles

Enterprise

1.70 miles

SIXT Rent a Car San Francisco Int Airport

1.71 miles

Hertz

1.72 miles

Budget

1.72 miles

National

1.72 miles

夜市 The Night Market

0.05 miles

Little Green Cyclo

0.30 miles

Basque Cultural Center

0.39 miles

47 Hills Brewing Company

0.42 miles

El Faro

0.50 miles

Taco Bell

0.50 miles

Royal Pin Donuts

0.51 miles

Pizza Hut

0.51 miles

McDonald's

0.54 miles

Smart & Final

0.54 miles

Lucky

0.54 miles

Marshalls

0.64 miles

Target

0.80 miles

The Shops at Tanforan

0.81 miles

JCPenney

0.87 miles

Pacific Supermarket

0.98 miles

La Hacienda Market

1.21 miles

Mollie Stone's Markets

1.58 miles

San Bruno Police Department

0.72 miles

South San Francisco Police Department

0.95 miles

Fire Station 63

1.06 miles

Kaiser Permanente South San Francisco Medical Center

1.33 miles

Sunshine Pharmacy

1.42 miles

SSF Fire Station

1.51 miles

SBFD - Station 51

1.68 miles

SFO Marine Emergency Response Facility

2.14 miles

SBFD - Station 52

2.19 miles

220 S Spruce Ave Listing Summary

  • Office Space Available at 220 S Spruce Ave

    Office space currently available at 220 S Spruce Ave adds up to a total of 3,828 square feet across 2 listing(s). The largest individual space listed offers 2,160 square feet. Property use types available for lease at this property include: general office.

  • Learn More about 220 S Spruce Ave

    220 S Spruce Ave is located in the San Francisco market and pertains to the 94080 zip code. The property incorporates a total of 3,828 square feet of space. 220 S Spruce Ave features a parking ratio of 4.00 / 1,000 SF. 220 S Spruce Ave was built in 1984.

    Interested in researching more about this property? Access in-depth research on 220 S Spruce Ave, including ownership details, transaction history, property characteristics, taxes, mortgage data, violations and more by creating a free account and viewing the full property report.

  • Get to Know the Neighborhood

    In the Orange Park neighborhood, where 220 S Spruce Ave is located, you can currently find 11 office space(s) for rent. In total, this amounts to 16,723 square feet of available office space for lease opportunities.

Contact Listing Broker
broker
Mike Davis

Colliers

  1. 1Main information
  2. 2Extra information
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