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  1. Office Space
  2. MD
  3. Annapolis

451 Defense Highway

For Lease 850 SF

451 Defense Highway, Annapolis, MD 21401

The property is strategically located with quick access to downtown Annapolis, major highway corridors, and public transportation. The surrounding area provides a full complement of dining, retail, and service amenities — an advantage for both employee recruitment and day-to-day business operations.Looking for professional office space without the overhead? This mezzanine sublet space with it’s own staircase and access, delivers a smart, move- in-ready solution. At only $15/SF Full Service, you get 850 SF of private office space that includes 4 individual offices and a bullpen.

Key features

  • 850 SF of private office space
  • Direct access to I-97 & Route 50
  • Full Service Lease
  • Multi-tenant building

Rental Details

  • Number of spaces 1
  • Total square feet available 850 SF
  • For Lease $15.00/SF/YR
  • Space Type Flex - Office
  • Lease Type Full Service
  • Latest Update Oct 13, 2026
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Space Name Space Type Lease Rate Total Space Floor Lease Type Expand

1 Space Available

Space Name Space Type Lease Rate Total Space Floor Lease Type Expand
Unit B Flex - Office $15.00/SF/YR 850 SF 1 Full Service

Unit B

Space Type

Flex - Office

Lease Rate

$15.00/SF/YR

Additional Rent

Price on request

Total Space Available

850 SF

Floor

1

Divisible Space

850 - 850 SF

Available Date

Immediate

Lease Type

Full Service

Sublease

Yes

Sublease Expiry

Nov 30, 2031

451 Defense Highway
451 Defense Highway
451 Defense Highway
451 Defense Highway
451 Defense Highway
451 Defense Highway
451 Defense Highway
451 Defense Highway
451 Defense Highway
451 Defense Highway
451 Defense Highway
451 Defense Highway
451 Defense Highway
451 Defense Highway
451 Defense Highway
451 Defense Highway

Unit B

Space Type
Flex - Office
Lease Rate
$15.00/SF/YR
Total Space
850 SF
Floor
1
Lease Type
Full Service
Space Type

Flex - Office

Lease Rate

$15.00/SF/YR

Additional Rent

Price on request

Total Space Available

850 SF

Floor

1

Divisible Space

850 - 850 SF

Available Date

Immediate

Lease Type

Full Service

Sublease

Yes

Sublease Expiry

Nov 30, 2031

451 Defense Highway
451 Defense Highway
451 Defense Highway
451 Defense Highway
451 Defense Highway
451 Defense Highway
451 Defense Highway
451 Defense Highway
451 Defense Highway
451 Defense Highway
451 Defense Highway
451 Defense Highway
451 Defense Highway
451 Defense Highway
451 Defense Highway
451 Defense Highway

Contacts

SD
Scott Douglas

Douglas Commercial

Building Details

  • For Lease $15.00/SF/YR
  • Property Type Office - General Office
  • Property Size 23,100 SF
  • Lot Size 4.3 Acre
  • Additional Rent Price on request
  • Property Tenancy Multi-Tenant
  • Building Class B
  • Year Built 2000
  • Date Updated Oct 13, 2026

Location

  • City Annapolis, MD
  • Zip Code 21401
  • Market Baltimore
  • Map
  • Street
  • Walk score 11/100 Car-Dependent
  • Bike score 15/100 Somewhat Bikeable
Powered by Walk Score ®

Points of Interest

BP

0.42 miles

Exxon

1.13 miles

Blink

1.19 miles

Sam's Club Gas Station

1.45 miles

Shell

2.05 miles

Tesla Supercharger

2.07 miles

Liberty

2.11 miles

Carroll Motor Fuels

3.03 miles

Giant Food

3.23 miles

EVsmart

4.40 miles

Harry S. Truman Park and Ride

1.34 miles

Orange Garage

1.59 miles

Collins Aerospace Visitor Parking

1.68 miles

Collins Aerospace Employee Parking

1.73 miles

Red Garage

1.73 miles

Blue Garage

1.85 miles

Parking Garage D

2.13 miles

Parking Garage E

2.14 miles

Parking Garage C

2.29 miles

Parking Garage B

2.31 miles

U-Haul

1.62 miles

Mister Car Wash

2.19 miles

Hertz

2.48 miles

Budget

2.53 miles

Autobell Car Wash

2.88 miles

Enterprise

2.96 miles

Flagship

3.52 miles

Ecoxpress

4.07 miles

Exxon Car Wash

5.25 miles

Great American Car Wash

5.80 miles

Mylde Drynks

0.94 miles

Cheesecake

0.98 miles

Ales Beer Wines

1.00 miles

Queen's Orchard

1.02 miles

The Regal Inn

1.02 miles

Mylde Drinks

1.02 miles

Sakura Sushi

1.17 miles

Wendy's

1.18 miles

Eggcellence

1.18 miles

Papa John's

1.19 miles

Safeway

1.18 miles

Macy's

1.62 miles

Annapolis Mall

1.76 miles

JCPenney

1.80 miles

Giant

1.85 miles

TJ Maxx

1.92 miles

The Fresh Market

1.95 miles

Marshalls

2.01 miles

Trader Joe's

2.01 miles

Target

2.03 miles

First Aid

1.02 miles

Luminis Health J Kent Mcnew Family Medical Center

1.26 miles

Annapolis Neurology Associates

1.38 miles

Chesapeake Medical Imaging

1.39 miles

NOAA Fisheries

1.80 miles

PM Pediatric Urgent Care

1.91 miles

Lesly and Pat Sajak Pavilion

2.15 miles

Patient First

2.16 miles

John and Kathy Belcher Pavilion

2.17 miles

Pediatric Cardiology of Maryland

2.28 miles

Listing Summary

  • Asking Prices

    At 451 Defense Highway, the asking rate for office space for lease starts at $15.00/SF/YR.

  • Available Office Space

    Office space currently available at 451 Defense Highway adds up to a total of 850 square feet across 1 space.

    Property use types available for lease at this property include: flex - office.

    Sublease opportunities at 451 Defense Highway include 1 space.

  • Property Details

    The property incorporates a total of 23,100 square feet of space.

    Interested in researching more about this property? Access in-depth research on 451 Defense Highway, including ownership details, transaction history, property characteristics, by creating a free account and viewing the full property report.

Contact Scott Douglas
SD
Scott Douglas

Douglas Commercial

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