For Sale

Innovation Square

2220 E 105th St, Cleveland, OH 44010

This highly visible development site lies within Cleveland’s transformative Opportunity Corridor, connecting I-490 to University Circle through the heart of the Fairfax neighborhood. The site—just steps from the Cleveland Clinic Main Campus—is surrounded by public and private investments reshaping the area into a hub for innovation, healthcare, and mixed-use development. Nearby residential projects like Axis at Ansel (163 units) and Innova (177 units) support a growing, walkable community. Additionally, the property is within walking distance to the new Fairfax Meijer, a full-service grocery and neighborhood anchor.

Key features

  • .70 AC available for ground lease or sale within the Opportunity Corridor
  • Adjacent to Cleveland Clinic Main Campus and walking distance to Fairfax Meijer, Medley Apartments, and Saucy Brew Works
  • Less than 1 mile from Case Western Reserve University and University Circle
  • Potential to expand assemblage
  • Prime land assemblage with visibility and access
  • Surrounded by over 700+ apartment unites within a 1/2 mile radius, including Medley, Axis at Ansel, Aura at Innovation Square, and Skyline on Stokes
Want more info on this listing?

Reach out to the broker for more info on lease terms and amenities

Contacts

Hanna Trolli

Passov Real Estate Group

Building Details

  • For Sale Subject To Offer
  • Property Type VacantLand
  • Lot Size 0.7 Acre
  • Date Updated Feb 23, 2026

Getting Around

  • Walk Score ®

    Somewhat Walkable (60)

  • Transit Score ®

    Good Transit (59)

  • Bike Score ®

    Somewhat Bikeable (45)
Powered by Walk Score ®

Location

  • City Cleveland, OH
  • Neighborhood Fairfax
  • Zip Code 44010
  • Market Cleveland Akron

Points of Interest

East 79th

1.49 miles

Coventry

1.89 miles

Superior

2.16 miles

East 55th

2.23 miles

Stokes-Windermere Station

2.78 miles

South Harbor

3.85 miles

East 9th–North Coast

4.11 miles

Cleveland Amtrak

4.22 miles

Settlers Landing

4.40 miles

Sunoco

0.94 miles

Fuel Point

1.10 miles

Get Go

1.15 miles

Gas USA

1.36 miles

BP

1.48 miles

Valero

1.76 miles

Shell

1.78 miles

Ohio Gas

1.83 miles

South-East Harley Davidson

7.53 miles

W. O. Walker Center Garage

0.35 miles

VISITOR LOT Lot S-63

0.60 miles

Cleveland Clinic Parking (P1) - Elevators On SE Corner - Pedestrian Tunnel On Basement (B) Level

0.61 miles

Underground and Surface Parking

0.61 miles

Guest Parking 10 min.

0.61 miles

Lot 13

0.64 miles

Veale Center Parking Garage

0.64 miles

SP+ Lot 82

0.67 miles

UH Parking Garage

0.67 miles

Carnegie Auto Wash And Detail Center

2.41 miles

Enterprise

2.95 miles

Pro Clean

3.28 miles

Mobil Car Wash

3.49 miles

Waterway Express

4.09 miles

BP

4.38 miles

Clean Express Auto Wash

5.08 miles

Ultimate Wash

6.23 miles

Goo Goo Express Car Wash

6.59 miles

Domino's

0.59 miles

Penn Station

0.60 miles

Phuel Cafe

0.60 miles

Fluffy Duck Cafe

0.60 miles

Urban Kitchen

0.61 miles

Table 45

0.63 miles

Einstein Bros. Bagels

0.73 miles

Atrium Café

0.74 miles

Burger King

0.76 miles

Simon's

1.04 miles

Plum Market

1.07 miles

ALDI

1.17 miles

Dave's Supermarket

1.61 miles

Dave's

1.76 miles

Save-A-Lot

1.88 miles

5th Street Arcades

3.82 miles

Galleria at Erieview

3.88 miles

Burlington

3.97 miles

Cole Mall

0.34 miles

Cleveland Clinic

0.43 miles

Cleveland Fire Station #10

0.53 miles

Rite Aid

0.54 miles

University Hospitals Otis Moss Jr. Health Center

0.56 miles

Walgreens

0.59 miles

Level 1 Trauma Center

0.72 miles

UH Rainbow Babies & Children’s Hospital

0.72 miles

Bolwell

0.80 miles

2220 E 105th St Listing Summary

  • What is the asking price at Innovation Square?

    The asking price for Innovation Square is currently available on demand. Contact the listing broker for details.

Contact Listing Broker
Hanna Trolli

Passov Real Estate Group

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