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  1. Industrial Space
  2. MO
  3. Cape Girardeau

500 William St

For Lease 21,984 SF

500 William St, Cape Girardeau, MO 63703

Situated in the heart of Cape Girardeau's industrial corridor, 500 William Street offers convenient access to major transportation routes, suppliers, and workforce populations throughout Southeast Missouri, Southern Illinois, and Western Kentucky. The property's central location provides efficient connectivity to Interstate 55, US Highway 61, and regional logistics networks, making it an ideal location for manufacturing, assembly, distribution, and industrial service operations.Flexible industrial space available for lease at 500 William Street in Cape Girardeau, Missouri. The property offers approximately 11,000 SF of total industrial space that can be leased in its entirety or demised into four individual suites ranging from approximately 2,000 SF to 3,300 SF. (make sure to check out the "Spaces" tab above to see each space) Designed for manufacturing and industrial users, the facility features commercial-grade power infrastructure, heavy-duty concrete floors capable of supporting machinery and equipment, and access to a shared loading dock with dedicated loading capabilities for each tenant. The flexible configuration allows tenants to lease only the space they need today while maintaining the opportunity to expand as operations grow. This property is ideally suited for manufacturing, fabrication, assembly, warehousing, distribution, contractor operations, and other industrial users seeking functional space in a strategic Cape Girardeau location.

Key features

  • Centrally located in Cape Girardeau
  • Commercial-grade electrical service
  • Dedicated dock door access for tenants
  • Excellent access to regional transportation corridors
  • Flexible expansion opportunities within the building
  • Four available industrial suites ranging from approximately 2,000 SF to 3,300 SF
  • Functional industrial layout
  • Heavy-duty concrete floors designed for industrial equipment and machinery
  • Ideal for manufacturing, fabrication, assembly, and distribution users
  • Lease individual suites or the entire facility
  • Manufacturing and industrial-zoned facility
  • Rare small-bay industrial leasing opportunity
  • Shared loading dock access
  • Suitable for owner-operated businesses, startups, and expanding manufacturers
  • Up to approximately 11,000 SF available

Rental Details

  • Number of spaces 5
  • Total square feet available 21,984 SF
  • For Lease $8.50/SF/YR
  • Space Type Warehouse/Distribution, Manufacturing, Flex - Industrial
  • Lease Type Full Service
  • Latest Update Jun 6, 2026
Want more info on this listing?

Reach out to the broker for more info on lease terms and amenities

True

5 Spaces Available

Space Name Space Type Lease Rate Total Space Floor Lease Type Expand
500 William Suite A Warehouse/Distribution $8.50/SF/YR 2,093 SF - Full Service

500 William Suite A

Space Type

Warehouse/Distribution

Lease Rate

$8.50/SF/YR

Additional Rent

Price on request

Total Space Available

2,093 SF

Divisible Space

2,093 - 2,093 SF

Available Date

Immediate

Lease Type

Full Service

Renewal Option

Yes

Sublease

No

500 William St
500 William St
500 William St
500 William St

Standard utility usage is included.

500 William Suite B Manufacturing $8.50/SF/YR 3,311 SF - Full Service

500 William Suite B

Space Type

Manufacturing

Lease Rate

$8.50/SF/YR

Additional Rent

Price on request

Total Space Available

3,311 SF

Divisible Space

3,311 - 3,311 SF

Available Date

Immediate

Lease Type

Full Service

Renewal Option

Yes

Sublease

No

500 William St
500 William St
500 William St
500 William St
500 William St
500 William St

Standard utility usage included.

500 William Suite C Flex - Industrial $8.50/SF/YR 2,483 SF - Full Service

500 William Suite C

Space Type

Flex - Industrial

Lease Rate

$8.50/SF/YR

Additional Rent

Price on request

Total Space Available

2,483 SF

Divisible Space

2,483 - 2,483 SF

Available Date

Immediate

Lease Type

Full Service

Renewal Option

Yes

Sublease

No

500 William St
500 William St
500 William St
500 William St
500 William St
500 William St
500 William St
500 William St
500 William St
500 William St
500 William St
500 William St
500 William St
500 William St
500 William St
500 William St

Standard utility usage included

500 William Suite D Flex - Industrial $8.50/SF/YR 3,105 SF - Full Service

500 William Suite D

Space Type

Flex - Industrial

Lease Rate

$8.50/SF/YR

Additional Rent

Price on request

Total Space Available

3,105 SF

Divisible Space

3,105 - 3,105 SF

Available Date

Immediate

Lease Type

Full Service

Renewal Option

Yes

Sublease

No

Standard utility usage included

500 William Suites A-D Flex - Industrial $8.50/SF/YR 10,992 SF - Full Service

500 William Suites A-D

Space Type

Flex - Industrial

Lease Rate

$8.50/SF/YR

Additional Rent

Price on request

Total Space Available

10,992 SF

Divisible Space

10,992 - 10,992 SF

Available Date

Immediate

Lease Type

Full Service

Renewal Option

Yes

Sublease

No

Standard utility usage included

500 William Suite A

Space Type
Warehouse/Distribution
Lease Rate
$8.50/SF/YR
Total Space
2,093 SF
Lease Type
Full Service
Space Type

Warehouse/Distribution

Lease Rate

$8.50/SF/YR

Additional Rent

Price on request

Total Space Available

2,093 SF

Divisible Space

2,093 - 2,093 SF

Available Date

Immediate

Lease Type

Full Service

Renewal Option

Yes

Sublease

No

500 William St
500 William St
500 William St
500 William St

Standard utility usage is included.

500 William Suite B

Space Type
Manufacturing
Lease Rate
$8.50/SF/YR
Total Space
3,311 SF
Lease Type
Full Service
Space Type

Manufacturing

Lease Rate

$8.50/SF/YR

Additional Rent

Price on request

Total Space Available

3,311 SF

Divisible Space

3,311 - 3,311 SF

Available Date

Immediate

Lease Type

Full Service

Renewal Option

Yes

Sublease

No

500 William St
500 William St
500 William St
500 William St
500 William St
500 William St

Standard utility usage included.

500 William Suite C

Space Type
Flex - Industrial
Lease Rate
$8.50/SF/YR
Total Space
2,483 SF
Lease Type
Full Service
Space Type

Flex - Industrial

Lease Rate

$8.50/SF/YR

Additional Rent

Price on request

Total Space Available

2,483 SF

Divisible Space

2,483 - 2,483 SF

Available Date

Immediate

Lease Type

Full Service

Renewal Option

Yes

Sublease

No

500 William St
500 William St
500 William St
500 William St
500 William St
500 William St
500 William St
500 William St
500 William St
500 William St
500 William St
500 William St
500 William St
500 William St
500 William St
500 William St

Standard utility usage included

500 William Suite D

Space Type
Flex - Industrial
Lease Rate
$8.50/SF/YR
Total Space
3,105 SF
Lease Type
Full Service
Space Type

Flex - Industrial

Lease Rate

$8.50/SF/YR

Additional Rent

Price on request

Total Space Available

3,105 SF

Divisible Space

3,105 - 3,105 SF

Available Date

Immediate

Lease Type

Full Service

Renewal Option

Yes

Sublease

No

Standard utility usage included

500 William Suites A-D

Space Type
Flex - Industrial
Lease Rate
$8.50/SF/YR
Total Space
10,992 SF
Lease Type
Full Service
Space Type

Flex - Industrial

Lease Rate

$8.50/SF/YR

Additional Rent

Price on request

Total Space Available

10,992 SF

Divisible Space

10,992 - 10,992 SF

Available Date

Immediate

Lease Type

Full Service

Renewal Option

Yes

Sublease

No

Standard utility usage included

Contacts

broker
Matt Huber

Lorimont Commercial Real Estate

Building Details

  • For Lease $8.50/SF/YR
  • Property Type Industrial - Warehouse/Distribution
  • Property Size 29,752 SF
  • Lot Size 1.5 Acre
  • Additional Rent Price on request
  • Date Updated Jun 6, 2026
  • HVAC

    None

Location

  • City Cape Girardeau, MO
  • Zip Code 63703
  • Map
  • Street
  • Walk score 64/100 Somewhat Walkable
  • Bike score 55/100 Bikeable
Powered by Walk Score ®

Points of Interest

Gordonville

8.90 miles

Jackson

9.41 miles

Iron Moountain Junction

9.62 miles

Kidd's gas station

1.61 miles

Rhodes

2.69 miles

Mobil

3.19 miles

Rhodes Travel Center

4.66 miles

Over the road truck parking

4.60 miles

Church overflow parking

5.59 miles

Cape Girardeau Police Department

0.17 miles

Southeast Hospital

1.13 miles

Walgreens

1.55 miles

Southeast Behavioral Hospital

2.44 miles

Saint Francis Medical Center

2.53 miles

MediCenter Pharmacy

2.68 miles

Cape Girardeau Station 4

3.39 miles

Autism Support Now

3.41 miles

Scott City Police Department

5.67 miles

Scott City Fire Department Station 1

5.67 miles

Kenny's Flippin Burgers

0.40 miles

Port Cape Girardeau Restaurant and Lounge

0.47 miles

Hardee's

1.34 miles

McDonald's

1.39 miles

Arby's

1.48 miles

Fazoli's

1.54 miles

Wendy's

1.54 miles

Watami Sushi & Hibachi Steakhouse

1.55 miles

Long John Silver's

1.55 miles

Captain D's

1.56 miles

Listing Summary

  • The Price for Industrial Space at 500 William St

    As is true of most real estate, the asking price for industrial space can vary based on factors such as the property location, proximity to transportation and shipping hubs, the property age, quality rating, and onsite facilities and features. At 500 William St, the asking rate is $8.50/SF/YR.

  • Industrial Space Options at 500 William St

    The facility offers a total of 29,752 square feet of rentable industrial space. Leasing opportunities here include Warehouse/Distribution space, Manufacturing space, Flex - Industrial space.

  • Key Amenities and Features at 500 William St

    The property at 500 William St features climate-control technology, and more.

Contact Matt Huber
broker
Matt Huber

Lorimont Commercial Real Estate

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