Florida Keys, FL Commercial Real Estate

Search commercial property for lease or for sale and view the Market Overview section below for local stats and insights.

78 Listings

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$1,995,000
718-720 Caroline Street
718-720 Caroline Street, Historic Seaport, Key West, FL
Property Type
Retail
Built in 1918

3,424 SF
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$7,950,000
12685 Overseas Hwy
12685 Overseas Hwy, Coco Plum, MARATHON, FL
Property Type
Other
Built in 1957

4,510 SF
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$2,500,000
532 Margaret Street
532 Margaret Street, Old Town Key West, Key West, FL
Property Type
Other
Built in 1958

2,490 SF
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$237,700
1010 Kennedy Dr 400
1010 Kennedy Dr 400, New Town Key West, Key West, FL
Property Type
Office
Built in 1978

2,337 SF
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$22.39 - $28.80/SF/YR
10035 Overseas Hwy Matathon
10035 Overseas Highway, Farara Shores, Marathon, FL
Space Type
Office
2 spaces

1,000 - 4,020 SF
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$5,000.00/MO
5300 Overseas Highway
5300 Overseas Highway, Stock Island, FL
Space Type
Retail
1 space

789 SF
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$799,000
24792 Overseas Highway
24792 Overseas Highway, Summerland Key, FL
Property Type
VacantLand
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$15,500.00/MO
518 Duval St
518 Duval St, Downtown Key West, Key West, FL
Space Type
Retail
1 space

2,155 SF
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$1,973.00/MO
Damaron Building
99198 Overseas Hwy, Sunset Cove, Key Largo, FL
Space Type
Office
1 space

1,000 SF
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$5.56 - $7.00/SF/MO
88101 Old Hwy, Islamorada FL 33036
88101 Overseas Highway, Plantation Beach, Islamorada, FL
Space Type
Office
3 spaces

100 - 125 SF
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$12.00/SF/MO
99451 Overseas Hwy 2nd Floor, Key Largo, FL 33037
99451 Overseas Highway, Port Largo, Key Largo, FL
Space Type
Office
1 space

5,457 SF
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$875,000
22814 Overseas Hwy
22814 Overseas Hwy, Cudjoe Key, Cudjoe, FL
Property Type
Other
Built in 1976

1,120 SF
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$2,950,000
81900 Overseas Hwy
81900 Overseas Hwy, Stratton's, Islamorada, FL
Property Type
Retail
Built in 1975

5,232 SF
1 of 1
$4,450.00/MO
418 Eaton Street
418 Eaton Street, Historic Seaport, Key West, FL
Space Type
Retail
1 space

971 SF
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$395,000
5701 Overseas Hwy
5701 Overseas Hwy, Sombrero Beach, MARATHON, FL
Property Type
Other
Built in 1979

1,128 SF
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$3,100,000
30330 Overseas Hwy
30330 Overseas Hwy, Big Pine Key, Big Pine, FL
Property Type
Other
Built in 1979

5,250 SF
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$1,200,000
3140 Northside Dr # F
3140 Northside Dr # F, New Town Key West, Key West, FL
Property Type
Office
Built in 1991

2,045 SF
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$4,549,000
818 Elizabeth St
818 Elizabeth St, Old Town Key West, Key West, FL
Property Type
Multi-Family
Built in 1928

5,317 SF
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$3,475,000
1215 Duval St
1215 Duval St, Upper Duval, Key West, FL
Property Type
Retail
Built in 1953

2,244 SF
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$1,400,000
7070 Overseas Hwy
7070 Overseas Hwy, Roosevelt Point, MARATHON, FL
Property Type
Other
Built in 1954

4,168 SF
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$489,000
11400 Overseas Hwy
11400 Overseas Hwy, Key Colony, MARATHON, FL
Property Type
Other
Built in 1973

1,350 SF
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$1,250,000
1421 First Street
1421 First Street, New Town Key West, Key West, FL
Property Type
Office
1,393 SF
1 of 1
$7,500.00/MO
408 Greene St
408 Greene St, Historic Seaport, Key West, FL
Space Type
Retail
1 space

1,398 SF
1 of 1
$5,300.00 - $5,828.00/MO
431 Front Street
431 Front Street, Historic Seaport, Key West, FL
Space Type
Retail
2 spaces

326 - 657 SF
1 of 1
$18,052.00/MO
400 Duval Street
400 Duval Street , Historic Seaport, Key West, FL
Space Type
Retail
1 space

1,733 SF
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$12,250,000
Looe Key Reef Resort
27340 Overseas Highway, Ramrod Key, FL
Property Type
Other
Built in 1958

10,956 SF
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$1,850,000
701 Simonton St
701 Simonton St, Old Town Key West, Key West, FL
Property Type
Other
Built in 1938

1,745 SF
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Price on request
207 Key Deer Boulevard
207 Key Deer Boulevard, Big Pine Key, FL
Space Type
Retail
6 spaces

900 - 2,400 SF
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$265,000
5701 Overseas Hwy
5701 Overseas Hwy, Sombrero Beach, MARATHON, FL
Property Type
Other
Built in 1979

947 SF
1 of 1
$10,500.00/MO
221 Duval St
221 Duval St, Historic Seaport, Key West, FL
Space Type
Retail
1 space

635 SF
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$1,850,000
701 Simonton St
701 Simonton St, Old Town Key West, KEY WEST, FL
Property Type
Other
Built in 1938

1,745 SF
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$700.00 - $1,600.00/MO
524 Eaton Street
524 Eaton Street, Historic Seaport, Key West, FL
Space Type
Office
5 spaces

70 - 320 SF
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$2,750.00 - $5,250.00/MO
Galleon Square - Spaces For Lease
218 Whitehead St, Truman Annex, Key West, FL
Space Type
Mixed Use
3 spaces

501 - 1,407 SF
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$3,100,000
74560 Overseas Hwy
74560 Overseas Hwy, Port Antigua, ISLAMORADA, FL
Property Type
Other
Built in 1983

6,071 SF
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$895,000
30582 5th Ave
30582 5th Ave, Big Pine Key, FL
Property Type
VacantLand
Built in 1976

2,192 SF
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$3,250.00/MO
802 White Street
802 White Street, Old Town Key West, Key West, FL
Space Type
Office
1 space

994 SF
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$950.00 - $2,200.00/MO
626 Josephine Parker Dr
626 Josephine Parker Dr, Downtown Key West, Key West, FL
Space Type
Office
2 spaces

330 - 340 SF
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$3,500,000
678 Mini Storage
323 Overseas Hwy, Big Coppitt Key, Key West, FL
Property Type
Other
Built in 2020

6,912 SF
1 of 1
$8,900.00/MO
419 Duval St
419 Duval St, Historic Seaport, Key West, FL
Space Type
Retail
1 space

900 SF
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$415,000
68200 Overseas Hwy
68200 Overseas Hwy, Layton, LAYTON, FL
Property Type
Other
Built in 1978

800 SF

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Florida Keys, FL Commercial Real Estate Market Overview: Key Trends & Insights

Florida Keys has 156,412 square feet of commercial real estate inventory as of 2026. This inventory is distributed across nearly 100 properties.

This overview provides a snapshot of the Florida Keys commercial sector, highlighting the most important aspects and trends to guide you through the local landscape, whether you are looking to lease or invest in local CRE assets.

Commercial Space for Rent in Florida Keys, FL

Based on the latest estimates, Florida Keys, FL offers almost 100 commercial listings for lease, totaling about 156,412 square feet.

Current leasing options comprise 13 office listings, which represent approximately 37.14% out of the total leasing inventory. There is also 1 industrial and warehouse listing, making up 2.86% of the total. Additionally, 21 retail listings make up 60.00% of the local leasing market. These types are supplemented by 2 listings for lease belonging to other commercial types.

Property type No. of Listings Total Sq. Ft. Avg. Asking Rent

Office 13 62,519 N/A

Retail 21 514,437 $77.46

Industrial 1 1,948 N/A

Other 2 52,405 N/A

Commercial Real Estate for Sale in Florida Keys, FL

As of 2026, Florida Keys, FL has a total of 38 commercial real estate properties for sale.

This inventory includes 5 office assets, 1 industrial facilities and 6 retail properties available for purchase.

The largest share is held by Retail, with 15.79% out of local properties for sale belonging to this asset type. Office has the next largest share at 13.16%, while Industrial makes up 2.63% of commercial properties for sale in Florida Keys.

Property type No. of Listings Total Sq. Ft.

Office 5 62,519

Retail 6 514,437

Industrial 1 1,948

Other 26 201,686

Leading Commercial Real Estate Submarkets by Property Type in Florida Keys, FL

The leading commercial real estate submarkets for different property types in Florida Keys are:

Office: Historic Seaport with 6 office listings, totaling 2,232 square feet.
Retail: Historic Seaport with 12 retail listings, totaling 22,322 square feet.