Florida Keys, FL Commercial Real Estate

Search commercial property for lease or for sale and view the Market Overview section below for local stats and insights.

80 Listings

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$4,950,000
38 Coco Plum
38 Coco Plum Drive, Coco Plum, Marathon, FL
Property Type
Unassigned
Built in 1994

5,439 SF
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$12,900,000
Bahia Bay
97340 Overseas Highway, Mandalay, Key Largo, FL
Property Type
Unassigned
Built in 1994

20,084 SF
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$3,600,000
678 Mini Storage
323 Overseas Hwy, Big Coppitt Key, Key West, FL
Property Type
Other
Built in 2020

6,912 SF
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3 of 3
Price on request
207 Key Deer Boulevard
207 Key Deer Boulevard, Big Pine Key, FL
Space Type
Retail
6 spaces

900 - 2,400 SF
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$2,500,000
532 Margaret Street
532 Margaret Street, Old Town Key West, Key West, FL
Property Type
Other
Built in 1958

2,490 SF
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$999,000
BPK Shopping Center
30200 Overseas Highway, Big Pine Key, FL
Property Type
Unassigned
Built in 1970

3,200 SF
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$6,800,000
Old Tav
90311 Old Highway, Tropical Atlantic Shores, Tavernier, FL
Property Type
Unassigned
Built in 1981

10,714 SF
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$1,200,000
3140 Northside Dr # F
3140 Northside Dr # F, New Town Key West, Key West, FL
Property Type
Office
Built in 1991

2,045 SF
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$4,950,000
Casa Antigua
314 Simonton St, Historic Seaport, Key West, FL
Property Type
Multi-Family
Built in 1921

8,472 SF
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$4,400,000
218 Whitehead St
218 Whitehead St, Truman Annex, Key West, FL
Property Type
Retail
Built in 1942

7,755 SF
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$875,000
22814 Overseas Hwy
22814 Overseas Hwy, Cudjoe Key, Cudjoe, FL
Property Type
Other
Built in 1976

1,120 SF
1 of 1
$7,500.00/MO
408 Greene St
408 Greene St, Historic Seaport, Key West, FL
Space Type
Retail
1 space

1,398 SF
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$5.56 - $7.00/SF/MO
88101 Old Hwy, Islamorada FL 33036
88101 Overseas Highway, Plantation Beach, Islamorada, FL
Space Type
Office
3 spaces

100 - 125 SF
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$1,850,000
701 Simonton St
701 Simonton St, Old Town Key West, Key West, FL
Property Type
Other
Built in 1938

1,745 SF
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$1,450,000
7070 Overseas Hwy
7070 Overseas Hwy, Roosevelt Point, MARATHON, FL
Property Type
Other
Built in 1954

4,168 SF
1 of 1
$18,052.00/MO
400 Duval Street
400 Duval Street , Historic Seaport, Key West, FL
Space Type
Retail
1 space

1,733 SF
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$22.39 - $28.80/SF/YR
10035 Overseas Hwy Matathon
10035 Overseas Highway, Farara Shores, Marathon, FL
Space Type
Office
2 spaces

1,000 - 4,020 SF
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$2,400,000
88701 Overseas Hwy
88701 Overseas Hwy, Plantation Beach, Tavernier, FL
Property Type
Other
Built in 1999

1,957 SF
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2 of 2
$3,900.00/MO
1213 Truman Ave
1213 Truman Ave, The Meadows, Key West, FL
Space Type
Office
1 space

1,020 SF
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$950.00 - $2,200.00/MO
626 Josephine Parker Dr
626 Josephine Parker Dr, Downtown Key West, Key West, FL
Space Type
Office
2 spaces

330 - 340 SF
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$12.00/SF/MO
99451 Overseas Hwy 2nd Floor, Key Largo, FL 33037
99451 Overseas Highway, Port Largo, Key Largo, FL
Space Type
Office
1 space

5,457 SF
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$5,850,000
421 - 423 Simonton Street
421 - 423 Simonton Street, Historic Seaport, Key West, FL
Property Type
Other
Built in 2020

3,010 SF
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$415,000
68200 Overseas Hwy
68200 Overseas Hwy, Layton, LAYTON, FL
Property Type
Other
Built in 1978

800 SF
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$489,000
11400 Overseas Hwy
11400 Overseas Hwy, Key Colony, MARATHON, FL
Property Type
Other
Built in 1973

1,350 SF
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$799,000
24792 Overseas Highway
24792 Overseas Highway, Summerland Key, FL
Property Type
VacantLand
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$4,300.00 - $6,000.00/MO
1010 Kennedy Dr
1010 Kennedy Dr, New Town Key West, Key West, FL
Space Type
Office
2 spaces

1,475 - 2,058 SF
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$3,300,000
74560 Overseas Hwy
74560 Overseas Hwy, Port Antigua, ISLAMORADA, FL
Property Type
Other
Built in 1983

6,071 SF
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2 of 2
$4,500.00/MO
6150 2nd St
6150 2nd St, Stock Island, Key West, FL
Space Type
Retail
1 space

3,618 SF
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$3,675,000
1215 Duval St
1215 Duval St, Upper Duval, Key West, FL
Property Type
Other
Built in 1953

2,244 SF
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$237,700
1010 Kennedy Dr 400
1010 Kennedy Dr 400, New Town Key West, Key West, FL
Property Type
Office
Built in 1978

2,337 SF
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$6,995,000
Treasure Harbor Marina
200 Treasure Harbor Drive, Treasure Harbor, Islamorada, FL
Property Type
Other
Built in 1948

1,069 SF
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$12,250,000
Looe Key Reef Resort
27340 Overseas Highway, Ramrod Key, Cudjoe Key, FL
Property Type
Other
Built in 1958

10,956 SF
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$4,550.00 - $4,650.00/MO
607 Fleming Street
607 Fleming St, Historic Seaport, Key West, FL
Space Type
Retail
2 spaces

805 - 1,496 SF
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$1,250,000
1421 First Street
1421 First Street, New Town Key West, Key West, FL
Property Type
Office
1,393 SF
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$2,200,000
6950 Overseas Hwy
6950 Overseas Hwy, Roosevelt Point, MARATHON, FL
Property Type
Other
Built in 1984

2,762 SF
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$15,500.00/SF/YR
518 Duval St
518 Duval St, Downtown Key West, Key West, FL
Space Type
Office
1 space

2,155 SF
1 of 1
$10,500.00/MO
221 Duval St
221 Duval St, Historic Seaport, Key West, FL
Space Type
Retail
1 space

500 SF
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$2,199,000
Dairy Queen Key Largo
92661 Overseas Highway, Seaside, Key Largo, FL
Property Type
Unassigned
Built in 1973

1,796 SF
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$6,799,000
29740 Overseas Hwy
29740 Overseas Hwy, Big Pine Key, Big Pine, FL
Property Type
Other
Built in 1968

14,198 SF
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$2,750.00 - $5,250.00/MO
Galleon Square - Spaces For Lease
218 Whitehead St, Truman Annex, Key West, FL
Space Type
Mixed Use
3 spaces

501 - 1,407 SF

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Florida Keys, FL Commercial Real Estate Market Overview: Key Trends & Insights

Florida Keys has 252,504 square feet of commercial real estate inventory as of 2026. This inventory is distributed across nearly 100 properties.

This overview provides a snapshot of the Florida Keys commercial sector, highlighting the most important aspects and trends to guide you through the local landscape, whether you are looking to lease or invest in local CRE assets.

Commercial Space for Rent in Florida Keys, FL

Based on the latest estimates, Florida Keys, FL offers almost 100 commercial listings for lease, totaling about 252,504 square feet.

Current leasing options comprise 17 office listings, which represent approximately 50.00% out of the total leasing inventory. Additionally, 17 retail listings make up 50.00% of the local leasing market. These types are supplemented by 1 listing for lease belonging to other commercial types.

Property type No. of Listings Total Sq. Ft. Avg. Asking Rent

Office 17 216,294 N/A

Retail 17 482,387 $84.87

Other 1 47,725 N/A

Commercial Real Estate for Sale in Florida Keys, FL

As of 2026, Florida Keys, FL has a total of 42 commercial real estate properties for sale.

This inventory includes 3 office assets, 1 industrial facilities and 4 retail properties available for purchase.

The largest share is held by Retail, with 9.52% out of local properties for sale belonging to this asset type. Office has the next largest share at 7.14%, while Industrial makes up 2.38% of commercial properties for sale in Florida Keys.

Property type No. of Listings Total Sq. Ft.

Office 3 216,294

Retail 4 482,387

Industrial 1 1,948

Other 34 280,388

Leading Commercial Real Estate Submarkets by Property Type in Florida Keys, FL

The leading commercial real estate submarkets for different property types in Florida Keys are:

Office: Mandalay with 13 office listings, totaling 103,129 square feet.
Retail: Historic Seaport with 11 retail listings, totaling 16,687 square feet.