Sikeston, MO Commercial Real Estate

Search commercial property for lease or for sale and view the Market Overview section below for local stats and insights.

15 Listings

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$12.00/SF/YR
Midtowner Village
925-1077 E Malone Ave, Sikeston, MO
Space Type
Retail
3 spaces

1,400 - 10,295 SF
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$3,999.00/MO
328 S. Interstate Dr.
328 South Interstate Drive, Miner, Sikeston, MO
Space Type
Industrial
1 space

9,234 SF
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$2,213.75 - $3,682.00/MO
1100 - 1105 S. Main
1100 - 1105 S. Main, Sikeston, MO
Space Type
Retail
2 spaces

3,542 - 7,364 SF
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$979,500
808 E Wakefield Ave
808 E Wakefield Ave, Sikeston, MO
Property Type
Office
Built in 1988

11,450 SF
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$399,000
205 S New Madrid St
205 S New Madrid St, Sikeston, MO
Property Type
Industrial
Built in 1974

19,498 SF
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$4.25/SF/YR
Sikeston Commons
103 South Acres Drive, Sikeston, MO
Space Type
Industrial
1 space

210,000 SF
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$6.00 - $10.00/SF/YR
100 Outlet Drive
100 Outlet Drive, Miner, MO
Space Type
Retail
4 spaces

1,800 - 7,500 SF
$3,750,000
South Pointe Shopping Center
1209 - 1215 S Main St, Sikeston, MO
Property Type
Retail
49,173 SF
$775,000
10.65 Acre Industrial Lot
Highway 61 S, Sikeston, MO
Property Type
VacantLand
Price on request

Center Street Station
Center Street Station - Center St Station
104 East Center Street, Sikeston, MO
Space Type
Private Offices
$1,950.00/MO
600 N. Main Street
600 N. Main Street, Sikeston, MO
Space Type
Office
1 space

1,300 SF
$1,350,000
67 acres with Future I-57 frontage
Highway 61 S, Sikeston, MO
Property Type
VacantLand
1 SF
Price on request
1240 S Main Street
1240 S Main Street, Sikeston, MO
Property Type
VacantLand
0.31 Acre
$3,995,000
0 State Highway E
0 State Highway E, Sikeston, MO
Property Type
VacantLand
$975,000
15.5 Acre Industrial Lot
Highway 61 S, Sikeston, MO
Property Type
VacantLand

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Sikeston, MO Commercial Real Estate Market Overview: Key Trends & Insights

Sikeston has 261,949 square feet of commercial real estate inventory as of 2026. This inventory is distributed across nearly 100 properties.

This overview provides a snapshot of the Sikeston commercial sector, highlighting the most important aspects and trends to guide you through the local landscape, whether you are looking to lease or invest in local CRE assets.

Commercial Space for Rent in Sikeston, MO

Based on the latest estimates, Sikeston, MO offers almost 100 commercial listings for lease, totaling about 261,949 square feet.

Current leasing options comprise 1 office listing, which represent approximately 16.67% out of the total leasing inventory. There are also 2 industrial and warehouse listings, making up 33.33% of the total. Additionally, 3 retail listings make up 50.00% of the local leasing market.

Property type No. of Listings Total Sq. Ft. Avg. Asking Rent

Office 1 22,175 N/A

Retail 3 329,878 N/A

Industrial 2 238,732 N/A

Commercial Real Estate for Sale in Sikeston, MO

As of 2026, Sikeston, MO has a total of 6 commercial real estate properties for sale.

This inventory includes 1 office assets, 1 industrial facilities and 1 retail properties available for purchase.

The largest share is held by Office, with 16.67% out of local properties for sale belonging to this asset type. Retail has the next largest share at 16.67%, while Industrial makes up 16.67% of commercial properties for sale in Sikeston.

Property type No. of Listings Total Sq. Ft.

Office 1 22,175

Retail 1 329,878

Industrial 1 238,732

Other 3 13,505