Hilton Head Island, SC Commercial Real Estate

Search commercial property for lease or for sale and view the Market Overview section below for local stats and insights.

26 Listings

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Price on request
The Medical Pavilion at Hilton Head Hospital
39 Hospital Center Blvd, Hilton Head Island, SC
Space Type
Office
1 space

6,743 SF
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Price on request
±23,957 SF Freestanding Commercial Building
10 Target Rd, Hilton Head Island, SC
Space Type
Mixed Use
1 space

22,082 SF
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$849,000
High Visibility Retail For Sale
3 Regency Pkwy, Hilton Head Island, SC
Property Type
Retail
Built in 1987

2,250 SF
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$22.00/SF/YR
8,495 SF Conditioned Flex Space
16 Finch St, Hilton Head Island, SC
Space Type
Industrial
1 space

8,495 SF
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±1,600 - ±9,900-SF Industrial Space Available
5 Enterprise Ln, Hilton Head Island, SC
Space Type
Industrial
1 space

9,900 SF
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$1,550,000
Class A Office Building With Direct Frontage On Hwy 278
34 New Orleans Rd, Hilton Head Island, SC
Property Type
Office
Built in 2014

3,788 SF
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±2,100 to ±5,090 SF Flex Space Located off William Hilton Parkway
12 Cardinal Rd, Hilton Head Island, SC
Space Type
Industrial
1 space

5,090 SF
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Class "A" Office Space with Water Views
23B Shelter Cove Lane, Hilton Head Island, SC
Space Type
Office
3 spaces

1,017 - 7,268 SF
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$1,348,000
Stand Alone Medical & Office Building
4101 Main St, Suites E & F , Hilton Head Island, SC
Property Type
Office
Built in 2001

3,600 SF
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$15.25/SF/YR
29 Hunter Road
29 Hunter Rd, Hilton Head Island, SC
Space Type
Industrial
1 space

4,800 SF
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$5,800,000
±23,957 SF Freestanding Commercial Building
10 Target Rd, Hilton Head Island, SC
Property Type
Other
23,957 SF
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Northridge Plaza
435 William Hilton Pkwy, Hilton Head Island, SC
Space Type
Retail
5 spaces

1,000 - 5,600 SF
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$1,950,000
9,600 SF Office Building In Indigo Run
5 Dunmore Court, Hilton Head Island, SC
Property Type
Office
Built in 1999

9,600 SF
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$17.00/SF/YR
8 Lafayette Place
8 Lafayette Pl, Hilton Head Island, SC
Space Type
Office
1 space

3,025 SF
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$18.00/SF/YR
Class A Office Lease - Two Park Lane
2 Park Lane , Hilton Head Island, SC
Space Type
Office
2 spaces

1,792 - 2,615 SF
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$425,000
Flex Office Space
386 Spanish Wells Rd, Unit B-3, Hilton Head Island, SC
Property Type
Office
Built in 1986

2,175 SF
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$3,000.00/MO
Flex Office Space
386 Spanish Wells Rd, Unit B-3, Hilton Head Island, SC
Space Type
Office
1 space

2,175 SF
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$17.00 - $19.00/SF/YR
Stand Alone Medical & Office Building
4101 Main St, Suites E & F , Hilton Head Island, SC
Space Type
Office
3 spaces

1,286 - 3,600 SF
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$375,000
Office / Medical Space for Sale
23 Main Street, Suite 303, Hilton Head Island, SC
Property Type
Office
1,213 SF
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From $339/month
HQ - Hilton Head - Office Park Road
32 Office Park Road, Hilton Head Island, SC
Space Type
Private Offices
Space for 1 to 15 people
Price on request
Circle Center
70 Pope Avenue, Hilton Head Island, SC
Space Type
Retail
4 spaces

660 - 2,160 SF
From $40/day

The Common Loft
The Common Loft - 10 Hospital Center Commons
10 Hospital Center Commons #400, Hilton Head Island, SC
Space Type
Desks
Price on request
The Fresh Market Shoppes
890 William Hilton Pkwy, Hilton Head Island, SC
Space Type
Retail
2 spaces

1,600 - 2,360 SF
Price on request

Executive Suite of Hilton Head Island
Executive Suite of Hilton Head Island
2 Corpus Christi Place #200, Hilton Head Island, SC
Space Type
Private Offices
Space for 1 to 3 people
Price on request
Island Crossing
11 Palmetto Bay Road, Hilton Head Island, SC
Space Type
Retail
2 spaces

1,465 - 1,500 SF
Price on request
±1,600-SF Flex Space for Lease on Hilton Head Island
3 Hunter Rd, Hilton Head Island, SC
Space Type
Industrial
1 space

1,600 SF

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Hilton Head Island, SC Commercial Real Estate Market Overview: Key Trends & Insights

Hilton Head Island has 128,855 square feet of commercial real estate inventory as of 2026. This inventory is distributed across nearly 100 properties.

This overview provides a snapshot of the Hilton Head Island commercial sector, highlighting the most important aspects and trends to guide you through the local landscape, whether you are looking to lease or invest in local CRE assets.

Commercial Space for Rent in Hilton Head Island, SC

Based on the latest estimates, Hilton Head Island, SC offers almost 100 commercial listings for lease, totaling about 128,855 square feet.

Current leasing options comprise 7 office listings, which represent approximately 41.18% out of the total leasing inventory. There are also 5 industrial and warehouse listings, making up 29.41% of the total. Additionally, 5 retail listings make up 29.41% of the local leasing market. These types are supplemented by 1 listing for lease belonging to other commercial types.

Property type No. of Listings Total Sq. Ft. Avg. Asking Rent

Office 7 150,274 N/A

Retail 5 430,328 N/A

Industrial 5 27,386 N/A

Other 1 22,082 N/A

Commercial Real Estate for Sale in Hilton Head Island, SC

As of 2026, Hilton Head Island, SC has a total of 9 commercial real estate properties for sale.

This inventory includes 6 office assets and 1 retail properties available for purchase.

The largest share is held by Office, with 66.67% out of local properties for sale belonging to this asset type. Retail has the next largest share at 11.11% of commercial properties for sale in Hilton Head Island.

Property type No. of Listings Total Sq. Ft.

Office 6 150,274

Retail 1 430,328

Other 2 23,957