Cape Girardeau, MO Commercial Real Estate

Search commercial property for lease or for sale and view the Market Overview section below for local stats and insights.

65 Listings

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$2,250.00/MO
122 S. Spanish St.
122 S. Spanish St., Cape Girardeau, MO
Space Type
Office
1 space

5,225 SF
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$130,000
Lot 1 West Dr.
West Dr, Cape Girardeau, MO
Property Type
VacantLand
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$599,900
5728 Missouri 25
5728 Missouri 25, Gordonville, Cape Girardeau, MO
Property Type
Retail
Built in 1945

4,922 SF
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$18.00/SF/YR
820 N Sprigg St - Suites 3-4
820 N Sprigg St - Suites 3-4, Cape Girardeau, MO
Space Type
Retail
1 space

3,000 SF
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$1,899,900
5291 Missouri 25
5291 Missouri 25, Gordonville, Cape Girardeau, MO
Property Type
Office
Built in 2003

5,130 SF
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$2,708.33 - $7,800.00/MO
301 Broadway St
301 Broadway St, Cape Girardeau, MO
Space Type
Office
5 spaces

1,250 - 3,600 SF
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$6.00/SF/YR
Warehouse For Lease
211 N. Spring Ave., Unit C, Cape Girardeau, MO
Space Type
Industrial
1 space

13,875 SF
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$975,000
Spanish Street Mercantile
26 North Spanish Street, Cape Girardeau, MO
Property Type
Retail
Built in 1941

10,850 SF
1 of 1
$1,470.00/MO
1,600 SF Office Suite Available For Lease
760 S Kingshighway, Suite M, Cape Girardeau, MO
Space Type
Office
1 space

1,600 SF
1 of 1
$2,467.00/MO
Office/Retail Space For Lease
440 S. Mount Auburn Road, Cape Girardeau, MO
Space Type
Office
1 space

1,184 SF
1 of 1
$1,650.00/MO
West Park Village
2500 - 2536 William, Cape Girardeau, MO
Space Type
Retail
1 space

1,450 SF
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$899,900
13,694 SF Commercial Building in Historic Downtown
18 N. Main, Cape Girardeau, MO
Property Type
Office
13,694 SF
1 of 1
$99,900
2010 William
2010 William, Cape Girardeau, MO
Property Type
VacantLand
1 of 1
$3,000.00 - $5,250.00/MO
Town Plaza Shopping Center
2136 William St., Cape Girardeau, MO
Space Type
Retail
2 spaces

3,000 - 7,000 SF
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$150,000
1330 North Mount Auburn Road
1330 North Mount Auburn Road, Cape Girardeau, MO
Property Type
VacantLand
1 of 1
$130,000
Lots 2 & 3 West Dr.
West Dr, Cape Girardeau, MO
Property Type
VacantLand
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$199,000
2 Missouri 177
2 Missouri 177, Cape Girardeau, MO
Property Type
VacantLand
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$815,000
9,857 SF Medical Building in Doctor’s Park
10 Doctors Park, Cape Girardeau, MO
Property Type
Office
9,857 SF
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Contact Us!
Old Sprigg Land
Old Sprigg Land, Cape Girardeau, MO
Property Type
VacantLand
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$8.50/SF/YR
500 William St
500 William St, Cape Girardeau, MO
Space Type
Industrial
5 spaces

2,093 - 10,992 SF
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Price on request
45,000 SF LARGE-FORMAT RETAIL / FLEXIBLE COMMERCIAL SPACE
201 S Broadview St, Cape Girardeau, MO
Space Type
Retail
1 space

45,000 SF
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$2,500,000
The Library
10 S Spanish St, Cape Girardeau, MO
Property Type
Other
14,436 SF
1 of 1
$334,900
Independence & West Drive
Independence & West Drive, Cape Girardeau, MO
Property Type
VacantLand
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$8,558.75/MO
13,694 SF Commercial Building in Historic Downtown
18 N. Main, Cape Girardeau, MO
Space Type
Office
1 space

13,694 SF
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$270,000
2,546 SF Medical Office Building
62 Doctors Park, Cape Girardeau, MO
Property Type
Office
2,546 SF
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Price on request
3465 William
3465 William, Cape Girardeau, MO
Space Type
Retail
1 space

2,300 SF
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$1,500.00/MO
213 Clark Avenue
213 Clark Avenue, Cape Girardeau, MO
Space Type
Office
1 space

1,172 SF
1 of 1
Call for Pricing
0 County Road 205 - Subdivision
0 County Rd 205, Cape Girardeau, MO
Property Type
VacantLand
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$525,000
2004, 2020, 2024 Broadway St.
2004, 2020, 2024 Broadway St., Cape Girardeau, MO
Property Type
VacantLand
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$3,250.00/MO
2285 Sacajawea Lane
2285 Sacajawea Lane, Cape Girardeau, MO
Space Type
Industrial
1 space

4,576 SF
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$1,900.00/MO
2117 Broadway St. Suite B
2117 Broadway St. Suite B, Cape Girardeau, MO
Space Type
Retail
1 space

2,400 SF
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Price on request
221 Merriwether Street
221 Merriwether Street, Cape Girardeau, MO
Space Type
Office
1 space

1,300 SF
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Price on request
Brand New Neighborhood Lease Space Available
2510 Veterans Memorial Drive, Cape Girardeau, MO
Space Type
Retail
1 space

7,550 SF
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$80,000.00 per acre
387 Linebacker Run
387 Linebacker Run, Jackson, MO
Property Type
VacantLand
Built in 2014

2,731 SF
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$975.00/MO
1606 Independence St
1606 Independence St, Cape Girardeau, MO
Space Type
Retail
1 space

875 SF
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$300,000
Marquette Island
S Sprigg St, Cape Girardeau, MO
Property Type
VacantLand
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$4,950,000
Cape Centre
201 - 301 South Broadview Street, Cape Girardeau, MO
Property Type
Retail
81,605 SF
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Price on request
1330 Broadway St.
1330 Broadway St., Cape Girardeau, MO
Space Type
Retail
1 space

1,200 SF
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$200.00/MO
2441 Myra Dr
2441 Myra Dr, Cape Girardeau, MO
Space Type
Office
2 spaces

100 SF
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301 South Broadview Street
301 South Broadview Street, Cape Girardeau, MO
Space Type
Office
1 space

10,100 SF

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Cape Girardeau, MO Commercial Real Estate Market Overview: Key Trends & Insights

Cape Girardeau has 387,026 square feet of commercial real estate inventory as of 2026. This inventory is distributed across nearly 100 properties.

This overview provides a snapshot of the Cape Girardeau commercial sector, highlighting the most important aspects and trends to guide you through the local landscape, whether you are looking to lease or invest in local CRE assets.

Commercial Space for Rent in Cape Girardeau, MO

Based on the latest estimates, Cape Girardeau, MO offers almost 100 commercial listings for lease, totaling about 387,026 square feet.

Current leasing options comprise 12 office listings, which represent approximately 29.27% out of the total leasing inventory. There are also 6 industrial and warehouse listings, making up 14.63% of the total. Additionally, 23 retail listings make up 56.10% of the local leasing market. These types are supplemented by 1 listing for lease belonging to other commercial types.

Property type No. of Listings Total Sq. Ft. Avg. Asking Rent

Office 12 203,280 N/A

Retail 23 739,221 $10.33

Industrial 6 208,448 N/A

Other 1 20,474 N/A

Commercial Real Estate for Sale in Cape Girardeau, MO

As of 2026, Cape Girardeau, MO has a total of 26 commercial real estate properties for sale.

This inventory includes 4 office assets, 1 industrial facilities and 2 retail properties available for purchase.

The largest share is held by Office, with 15.38% out of local properties for sale belonging to this asset type. Retail has the next largest share at 7.69%, while Industrial makes up 3.85% of commercial properties for sale in Cape Girardeau.

Property type No. of Listings Total Sq. Ft.

Office 4 203,280

Retail 2 739,221

Industrial 1 208,448

Other 19 210,831