Saint Charles, MO Commercial Real Estate

Search commercial property for lease or for sale and view the Market Overview section below for local stats and insights.

134 Listings

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Price on request
University Commons
1900 First Capitol Drive, St. Charles, MO
Space Type
Retail
1 space

2,037 SF
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From $269/month

HQ
MO, Saint Charles - 3333-7 Rue Royale Street
3333-7 Rue Royale Street 1st Floor, Saint Charles, MO
Space Type
Private Offices
Space for 1 to 15 people
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2 of 2
$16.00/SF/YR
The Oak Creek Center
4045 N St Peters Pkwy, St. Peters, MO
Space Type
Retail
1 space

3,500 SF
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Contact Broker for Pricing
2781 Plaza Way
2781 Plaza Way, Saint Charles, MO
Property Type
Other
53,037 SF
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$24.50 - $28.00/SF/YR
SSM Health Medical Building 2
400 1st Capitol Drive, St. Charles, MO
Space Type
Office
2 spaces

1,989 - 2,608 SF
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$725,000
Historic Main Street Investment Opportunity
138 N Main St, Saint Charles, MO
Property Type
Mixed Use
Built in 1890

5,077 SF
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$24.50 - $28.00/SF/YR
SSM Health Medical Building 1
330 1st Capitol Drive, St. Charles, MO
Space Type
Office
11 spaces

1,486 - 4,439 SF
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$25.00/SF/YR
Turn-Key Gym Space - Historic Main Street
334 N Main St, Saint Charles, MO
Space Type
Retail
1 space

2,862 SF
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$325,000
501 Droste Rd
501 Droste Rd, Saint Charles, MO
Property Type
Land
23,849 SF
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3 of 3
Contact Broker for Pricing
500 Fountain Lakes Blvd
500 Fountain Lakes Blvd, Saint Charles, MO
Property Type
Office
Built in 2001

52,124 SF
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Price on request
Zumbehl Commons
1950 Zumbehl Road, St. Charles, MO
Space Type
Retail
5 spaces

1,160 - 10,726 SF
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$14.00/SF/YR
Main Street St. Charles Office Space For Lease
300 N Main Street, St Charles, MO
Space Type
Office
1 space

1,961 SF
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Price on request
Streets of St. Charles - 1520 South 5th Street
1520 South 5th Street, St. Charles, MO
Space Type
Office
5 spaces

747 - 2,153 SF
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$1,417,500
Jack in the Box
3710 Elm St, Saint Charles, MO
Property Type
Retail
Built in 1999

2,468 SF
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$22.00/SF/YR
Three Flags Center
1360 South 5th Street, St. Charles, MO
Space Type
Retail
2 spaces

1,100 - 2,160 SF
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From $30/day

OPO Startups
OPO Startups
119 South Main Street, Saint Charles, MO
Space Type
Desks
Space for up to 10 people
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2 of 2
$200,000
West Clay St & Spring Ave Land
West Clay St & Spring Ave, St. Charles, MO
Property Type
Land
0.78 Acre
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From $269/month

HQ
MO, Saint Charles - 3324 Rue Royale Street
3324 Rue Royale Street 1st Floor, Saint Charles, MO
Space Type
Private Offices
Space for 1 to 50 people
1 of 1
$500,000
St. Peters Pad Opportunity
8 Plaza Way St. Charles, Saint Charles, MO
Property Type
Land
42,689 SF
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2 of 3

3 of 3
Price on request
Streets of St. Charles - 1450 Beale Street
1450 Beale Street, St. Charles, MO
Space Type
Office
1 space

20,718 SF
1 of 3

2 of 3

3 of 3
$9.50/SF/YR
3613 Mueller Road
3613 Mueller Road, St. Charles, MO
Space Type
Industrial
1 space

65,800 SF
1 of 3

2 of 3

3 of 3
Price on request
Weldon Spring Center
1030-1116 Wolfrum, Weldon Spring, MO
Space Type
Retail
6 spaces

2,350 - 6,000 SF
1 of 1
$50,000
2795 McClay Rd
2795 McClay Rd, Saint Charles, MO
Property Type
Land
0.55 Acre
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$12.00/SF/YR
753A Friedens Road St. Charles
753 Friedens Rd, Saint Charles, MO
Space Type
Industrial
1 space

2,500 SF
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$1,450,000
Stabilized Main Street Investment Opportunity
213 N Main St, Saint Charles, MO
Property Type
Mixed Use
Built in 1890

4,524 SF
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$899,000
334 N Main Street St. Charles
334 N Main Street St. Charles, Saint Charles, MO
Property Type
Retail
5,712 SF
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2 of 2
Price on request
St. Peters Pad Opportunity
8 Plaza Way St. Charles, Saint Charles, MO
Space Type
Land
1 space

42,689 SF
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2 of 3

3 of 3
$16.50/SF/YR
500 Fountain Lakes Blvd
500 Fountain Lakes Blvd, Saint Charles, MO
Space Type
Office
1 space

14,859 SF
1 of 1
$1,388,605.68
Fountain Lakes Commerce Center - Lot I
I-370 and Elm Street, St. Charles, MO
Property Type
VacantLand
4,399,560 SF
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Price on request
Gutermuth Road Development Site
5335 Gutermuth Rd, Cottleville, Saint Charles, MO
Property Type
Land
Built in 1978

13.28 Acre
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Price on request
633 North Main Street
633 North Main Street, Saint Charles, MO
Space Type
Retail
1 space

5,705 SF
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$16.00 - $20.00/SF/YR
1600 Heritage Landing
1600 Heritage Landing, St. Charles, MO
Space Type
Office
7 spaces

150 - 3,068 SF
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$22.00/SF/YR
Woodstone Plaza
3910-3930 South Old Highway 94, Saint Charles, MO
Space Type
Office
8 spaces

330 - 2,336 SF
Price on request
Dierbergs Market at 370
3722 New Town Blvd, St. Charles, MO
Space Type
Land
1 space

109,335.6 SF
$2,614.00/MO
1125 N 2nd St
1125 N 2nd St, Saint Charles, MO
Space Type
Office
1 space

1,426 SF
Price on request
SouthPointe - Lot A
350 Hemsath Street, Saint Charles, MO
Property Type
VacantLand
1.47 Acre
Price on request
SouthPointe - Lot B
350 Hemsath Road, Saint Charles, MO
Property Type
VacantLand
Price on request
Building 2
540 Huber Park Ct, Weldon Spring, MO
Space Type
Industrial
1 space

9,452 SF
Price on request
6120-6140 Mid Rivers Mall Dr
6120-6140 Mid Rivers Mall Dr, St. Peters, MO
Space Type
Retail
1 space

1,600 SF
Price on request
South Ridge Shoppes
Highway N & Orf Road, Cottleville, Lake St. Louis, MO
Property Type
VacantLand
7.75 Acre

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Saint Charles, MO Commercial Real Estate Market Overview: Key Trends & Insights

Saint Charles has 2.5 million square feet of commercial real estate inventory as of 2026. This inventory is distributed across nearly 100 properties.

This overview provides a snapshot of the Saint Charles commercial sector, highlighting the most important aspects and trends to guide you through the local landscape, whether you are looking to lease or invest in local CRE assets.

Commercial Space for Rent in Saint Charles, MO

Based on the latest estimates, Saint Charles, MO offers almost 100 commercial listings for lease, totaling about 2.5 million square feet.

Current leasing options comprise 27 office listings, which represent approximately 38.03% out of the total leasing inventory. There are also 13 industrial and warehouse listings, making up 18.31% of the total. Additionally, 31 retail listings make up 43.66% of the local leasing market. These types are supplemented by 12 listings for lease belonging to other commercial types.

Property type No. of Listings Total Sq. Ft. Avg. Asking Rent

Office 27 958,910 N/A

Retail 31 1,134,526 $15.65

Industrial 13 440,581 N/A

Other 12 1,843,827 N/A

Commercial Real Estate for Sale in Saint Charles, MO

As of 2026, Saint Charles, MO has a total of 56 commercial real estate properties for sale.

This inventory includes 4 office assets, 6 industrial facilities and 6 retail properties available for purchase.

The largest share is held by Retail, with 10.71% out of local properties for sale belonging to this asset type. Industrial has the next largest share at 10.71%, while Office makes up 7.14% of commercial properties for sale in Saint Charles.

Property type No. of Listings Total Sq. Ft.

Office 4 958,910

Retail 6 1,134,526

Industrial 6 440,581

Other 40 9,521,093