Key West, FL Commercial Real Estate

Search commercial property for lease or for sale and view the Market Overview section below for local stats and insights.

37 Listings

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2 of 2
$3,200.00/MO
Conch Harbor
951 Caroline St, Historic Seaport, Key West, FL
Space Type
Office
1 space

1,200 SF
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$700.00 - $1,600.00/MO
524 Eaton Street
524 Eaton Street, Historic Seaport, Key West, FL
Space Type
Office
5 spaces

70 - 320 SF
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$1,200,000
3140 Northside Dr # F
3140 Northside Dr # F, New Town Key West, Key West, FL
Property Type
Office
Built in 1991

2,045 SF
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2 of 2
$4,635.00 - $26,276.25/MO
The Professional Plaza
1111 12th Street, New Town Key West, Key West, FL
Space Type
Office
3 spaces

1,235 - 7,007 SF
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$150,000
Boat Rental Business
Boat Rental Business, Beachside, Key West, FL
Property Type
Other
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$20,350,000
Southernmost Inn
521 United St, Upper Duval, Key West, FL
Property Type
Other
Built in 1938

12,183 SF
1 of 1
$5,300.00 - $5,828.00/MO
431 Front Street
431 Front Street, Historic Seaport, Key West, FL
Space Type
Retail
2 spaces

326 - 657 SF
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$5,000.00/MO
5300 Overseas Highway
5300 Overseas Highway, Stock Island, FL
Space Type
Retail
1 space

789 SF
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2 of 2
$4,500.00/MO
6150 2nd St
6150 2nd St, Stock Island, Key West, FL
Space Type
Retail
1 space

2,118 SF
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2 of 4

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4 of 4
$15,500.00/MO
518 Duval St
518 Duval St, Downtown Key West, Key West, FL
Space Type
Retail
1 space

2,155 SF
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5 of 5
$4,300.00 - $6,000.00/MO
1010 Kennedy Dr
1010 Kennedy Dr, New Town Key West, Key West, FL
Space Type
Office
2 spaces

1,475 - 2,058 SF
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$2,500,000
532 Margaret Street
532 Margaret Street, Old Town Key West, Key West, FL
Property Type
Other
Built in 1958

2,490 SF
1 of 1
$8,900.00/MO
419 Duval St
419 Duval St, Historic Seaport, Key West, FL
Space Type
Retail
1 space

900 SF
1 of 1
$4,450.00/MO
418 Eaton Street
418 Eaton Street, Historic Seaport, Key West, FL
Space Type
Retail
1 space

971 SF
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$4,549,000
818 Elizabeth St
818 Elizabeth St, Old Town Key West, Key West, FL
Property Type
Multi-Family
Built in 1928

5,317 SF
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$3,475,000
1215 Duval St
1215 Duval St, Upper Duval, Key West, FL
Property Type
Retail
Built in 1953

2,244 SF
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$237,700
1010 Kennedy Dr 400
1010 Kennedy Dr 400, New Town Key West, Key West, FL
Property Type
Office
Built in 1978

2,337 SF
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$3,250.00/MO
802 White Street
802 White Street, Old Town Key West, Key West, FL
Space Type
Office
1 space

994 SF
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$2,750.00 - $5,250.00/MO
Galleon Square - Spaces For Lease
218 Whitehead St, Truman Annex, Key West, FL
Space Type
Mixed Use
3 spaces

501 - 1,407 SF
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$1,850,000
701 Simonton St
701 Simonton St, Old Town Key West, Key West, FL
Property Type
Other
Built in 1938

1,745 SF
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$1,250,000
1421 First Street
1421 First Street, New Town Key West, Key West, FL
Property Type
Office
1,393 SF
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$1,995,000
718-720 Caroline Street
718-720 Caroline Street, Historic Seaport, Key West, FL
Property Type
Retail
Built in 1918

3,424 SF
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$1,850,000
701 Simonton St
701 Simonton St, Old Town Key West, KEY WEST, FL
Property Type
Other
Built in 1938

1,745 SF
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$4,950,000
Casa Antigua
314 Simonton St, Historic Seaport, Key West, FL
Property Type
Multi-Family
Built in 1921

8,472 SF
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$3,375,000
Dons’ Place Bar & Liquor Store
1000 Truman Avenue, Old Town Key West, Key West, FL
Property Type
Unassigned
Built in 1994

2,756 SF
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2 of 4

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4 of 4
$4,550.00 - $4,650.00/MO
607 Fleming Street
607 Fleming St, Historic Seaport, Key West, FL
Space Type
Retail
2 spaces

805 - 1,496 SF
1 of 1
$18,052.00/MO
400 Duval Street
400 Duval Street , Historic Seaport, Key West, FL
Space Type
Retail
1 space

1,733 SF
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$41,000.00/MO
100 Duval Street
100 Duval Street, Historic Seaport, Key West, FL
Space Type
Retail
1 space

5,500 SF
1 of 1
$10,500.00/MO
221 Duval St
221 Duval St, Historic Seaport, Key West, FL
Space Type
Retail
1 space

635 SF
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$4,200,000
218 Whitehead St
218 Whitehead St, Truman Annex, Key West, FL
Property Type
Retail
Built in 1942

7,755 SF
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$950.00 - $2,200.00/MO
626 Josephine Parker Dr
626 Josephine Parker Dr, Downtown Key West, Key West, FL
Space Type
Office
2 spaces

330 - 340 SF
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6 of 6
$16,500.00 - $48,683.00/MO
210-216 Duval Street
210-216 Duval Street, Historic Seaport, Key West, FL
Space Type
Retail
2 spaces

2,000 - 5,901 SF
1 of 1
$7,500.00/MO
408 Greene St
408 Greene St, Historic Seaport, Key West, FL
Space Type
Retail
1 space

1,398 SF
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$5,850,000
421 - 423 Simonton Street
421 - 423 Simonton Street, Historic Seaport, Key West, FL
Property Type
Other
Built in 2020

3,010 SF
1 of 4

2 of 4

3 of 4

4 of 4
Price on request
Key West, FL Marina
2407 N Roosevelt Blvd, New Town Key West, Key West, FL
Property Type
Other
From $950/month

RP Business Center
RP Business Center - 3706 North Roosevelt Blvd
3706 North Roosevelt Boulevard #208, Key West, FL
Space Type
Private Offices
Price on request
Fee Simple, Deep Water Basin in Key West, FL
6011 Peninsular Ave, Stock Island, Key West, FL
Property Type
Other

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Key West, FL Commercial Real Estate Market Overview: Key Trends & Insights

Key West has 48,545 square feet of commercial real estate inventory as of 2026. This inventory is distributed across more than properties.

This overview provides a snapshot of the Key West commercial sector, highlighting the most important aspects and trends to guide you through the local landscape, whether you are looking to lease or invest in local CRE assets.

Commercial Space for Rent in Key West, FL

Based on the latest estimates, Key West, FL offers more than commercial listings for lease, totaling about 48,545 square feet.

Current leasing options comprise 10 office listings, which represent approximately 47.62% out of the total leasing inventory. Additionally, 11 retail listings make up 52.38% of the local leasing market.

Property type No. of Listings Total Sq. Ft. Avg. Asking Rent

Office 10 24,394 N/A

Retail 11 78,607 $84.87

Leading Commercial Real Estate Submarkets by Property Type in Key West, FL

The leading commercial real estate submarkets for different property types in Key West are:

Office: Historic Seaport with 5 office listings, totaling 2,207 square feet.