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For Lease

321 Harrison Avenue

321 Harrison Avenue, Boston, MA 02118

18,333

SF Available

Rental Details

  • Number of spaces 1
  • Total square feet available 18,333 SF
  • For Lease Contact for pricing
  • Space Types General Office
  • Date Updated Jun 22, 2026
Want more info on this listing?

Reach out to the broker for more info on lease terms and amenities

True

For Lease 1 Space Available

4th Floor

  • Space Type General Office
  • Lease Rate Contact for pricing
  • Total Space Available 18,333 SF
  • Additional Space Type R&D - Office
  • Floor 4
  • Divisible Space 18,333 - 18,333 SF
  • Available Date Immediate
  • Renewal Option Yes
  • Sublease No

 100 PSF for Lab Space 

• 2 Conference Rooms • 4 Private Offices • 2 Huddle Rooms • 38 Work stations per plan • Café • Wellness Room LAB BREAKDOWN • 2 tissue support rooms • 1 specialized lab • 1 support room • 1 prep room • 4 Six Foot Hoods • 55 Lab Benches 

broker
Eric Smith

CBRE

broker
McKenna Repko

CBRE

broker
Tess S. Lawrence

CBRE

Contacts

broker
David Fitzgerald

CBRE

broker
Kristen Blumetti

CBRE

broker
Jeff Landers

CBRE

broker
Eric Smith

CBRE

broker
McKenna Repko

CBRE

broker
Tess S. Lawrence

CBRE

Building Details

  • For Lease Contact for pricing
  • Property Type Office - R&D - Office
  • Property Size 235,000 SF
  • Lot Size 1.92 Acre
  • Parking Spaces Avail. 242
  • Parking Ratio 1.03 / 1,000 SF
  • Property Tenancy Multi-Tenant
  • LEED Proposed Certified Silver
  • Building Class A
  • Year Built 2021
  • Date Updated Jun 22, 2026

Getting Around

  • Walk Score ®

    Walker's Paradise (98)
  • Transit Score ®

    Rider's Paradise (100)
  • Bike Score ®

    Very Bikeable (73)
Powered by Walk Score ®

Location

  • City Boston, MA
  • Neighborhood South End Boston
  • Zip Code 02118
  • Market Boston
  • Map
  • Street

Points of Interest

Broadway

0.44 miles

Boylston

0.48 miles

Boston Back Bay

0.57 miles

Back Bay

0.57 miles

South Station

0.63 miles

Downtown Crossing

0.66 miles

Green Line (Inbound) | Red Line (All Trains)

0.71 miles

Park Street

0.71 miles

Andrew

1.18 miles

ChargePoint

0.81 miles

Tesla Destination Charger

0.84 miles

Tesla Supercharger

0.85 miles

The Colonnade Hotel

0.86 miles

Shell

1.00 miles

Gulf

1.01 miles

Sunoco

1.09 miles

JuiceBar

1.36 miles

Stop & Shop Gas

1.44 miles

Underground at Ink Block Parking

0.17 miles

Hilton Doubletree

0.21 miles

Tremont Street Garage

0.25 miles

Atelier | 505 Garage

0.35 miles

Arlington Street Lot

0.36 miles

City Place Garage

0.39 miles

Motormart Garage

0.41 miles

Deer Park Maintenance Yard

0.45 miles

South Station Pick-up/Drop-off Parking

0.49 miles

Zipcar

0.76 miles

Enterprise

0.94 miles

Alamo

1.06 miles

Hertz Rent a Car Returns

2.23 miles

Alamo Car Rental Return

2.23 miles

Enterprise Rent-a-Car Returns

2.24 miles

National Car Rental Returns

2.24 miles

Budget Car Rental Returns

2.24 miles

SIXT Rent a Car Boston Int Airport

2.30 miles

Dunkin'

0.20 miles

Bootleg Special

0.24 miles

Rome Pizza

0.24 miles

Mike & Patty's

0.26 miles

Masa

0.27 miles

Sally's Sandwiches

0.27 miles

Blackbird Doughnuts

0.27 miles

Coppa

0.31 miles

Alex Pizza & Grill

0.31 miles

Whole Foods Market

0.08 miles

Ming's Supermarket

0.16 miles

Jia Ho Supermarket

0.35 miles

CityPlace

0.37 miles

Trader Joe's

0.58 miles

Macy's

0.61 miles

Neiman Marcus

0.65 miles

Roche Bros.

0.67 miles

Copley Place

0.72 miles

Floating Hospital for Children

0.25 miles

Tufts Medical Center

0.26 miles

Mass General Brigham Urgent Care

0.36 miles

Boston Fire Department Engine 7, Ladder 17

0.40 miles

Boston Fire Department Engine 3

0.49 miles

Boston Police Department, Area D-4

0.55 miles

Capsule

0.55 miles

Boston Police Department South Boston Neighborhood Station

0.58 miles

MBTA Transit Police

0.59 miles

321 Harrison Avenue Listing Summary

  • Office Space Available at 321 Harrison Avenue

    Office space currently available at 321 Harrison Avenue adds up to a total of 18,333 square feet across 1 listing(s). The largest individual space listed offers 18,333 square feet. Property use types available for lease at this property include: general office.

  • Learn More about 321 Harrison Avenue

    321 Harrison Avenue is located in the Boston market and pertains to the 02118 zip code. The property incorporates a total of 18,333 square feet of space. 321 Harrison Avenue features a parking ratio of 1.03 / 1,000 SF, offering a total of 242 parking spaces. 321 Harrison Avenue was built in 2021.

    Interested in researching more about this property? Access in-depth research on 321 Harrison Avenue, including ownership details, transaction history, property characteristics, taxes, mortgage data, violations and more by creating a free account and viewing the full property report.

  • Get to Know the Neighborhood

    In the South End Boston neighborhood, where 321 Harrison Avenue is located, you can currently find 72 office space(s) for rent. In total, this amounts to 1,560,420 square feet of available office space for lease opportunities.

Contact 321 Harrison Avenue
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