221 N Main St
221 N Main St, Natick, MA 01760
3,400
SF Available220 North Main Street in Natick offers renovated, flexible office space in a highly visible location on Route 27/9, with direct access to Natick Mall, Route 9, and major regional highways.
The three-story, locally owned and managed building features modern upgrades, on-site showers, ample parking, and walkable amenities—an efficient suburban office option for businesses seeking convenience, access, and a professional setting.
Rental Details
- Number of spaces 2
- Total square feet available 3,400 SF
- For Lease Contact for pricing
- Space Types Office
- Date Updated May 11, 2026
Reach out to the broker for more info on lease terms and amenities
True
For Lease 2 Spaces Available
Space Available |
Craig S. Johnston
R.W. Holmes
Dean Blackey
R.W. Holmes |
Space Available |
Craig S. Johnston
R.W. Holmes
Dean Blackey
R.W. Holmes |
Contacts
R.W. Holmes
R.W. Holmes
Building Details
- For Lease Contact for pricing
- Property Type Office
- Property Size 28,465 SF
- Date Updated May 11, 2026
Getting Around
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Walk Score ®
Very Walkable (73)
Location
- City Natick, MA
- Neighborhood Natick
- Zip Code 01760
- Market Worcester Springfield
Points of Interest
West Natick
2.10 miles
Framingham
3.58 miles
Wellesley Hills
4.24 miles
Wellesley Farms
4.65 miles
Needham Heights
6.31 miles
Eliot
7.39 miles
Hersey
7.55 miles
Waltham
8.08 miles
Southborough
8.82 miles
Gulf
0.78 miles
Sunoco
1.08 miles
Speedway
1.20 miles
Cumberland Farms
1.35 miles
Mobil
1.40 miles
Mabardy's Gulf
1.45 miles
Shell
1.74 miles
Tesla Supercharger
1.81 miles
ChargePoint
5.70 miles
MathWorks Apple Hill East Garage
0.49 miles
Car Parking
0.76 miles
Truck Parking
0.76 miles
Lakeside Parking Garage
0.89 miles
Cochituate North Lot
1.15 miles
Parking Deck C
1.18 miles
Parking Deck D
1.22 miles
Parking Deck E
1.28 miles
Premium Parking Deck B
1.28 miles
ScrubaDub
1.33 miles
Wellesley Car Wash
3.70 miles
The Clean Machine
4.46 miles
Enterprise rent-a-car
7.67 miles
Waltham Car Wash
8.13 miles
Quick & Clean Car Wash
8.47 miles
Zipcar
8.71 miles
Perfection Car Wash
9.07 miles
Panera Bread
0.01 miles
Chipotle
0.07 miles
Dunkin'
0.12 miles
Chuck E. Cheese's
0.17 miles
Culinary Delights
0.19 miles
Theo's
0.19 miles
Krua Thai
0.19 miles
Pizza Hut
0.21 miles
Mandarin Cafe
0.32 miles
Burlington
1.08 miles
ALDI
1.10 miles
Donelan's
1.11 miles
Nordstrom
1.21 miles
Shopper's Find
1.26 miles
Natick Mall
1.27 miles
Macy's
1.44 miles
Roche Bros.
1.67 miles
TJ Maxx
1.77 miles
Natick Police Department
1.35 miles
Wayland Fire Department
1.44 miles
CVS Pharmacy
1.46 miles
Walgreens
1.66 miles
MetroWest Medical Center: Leonard Morse Hospital
1.87 miles
Andrews Pharmacy
2.35 miles
Framingham Fire Department
2.47 miles
Campus Police
2.57 miles
State Police Station H-2, Framingham
2.84 miles
221 N Main St Listing Summary
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Office Space Available at 221 N Main St
Office space currently available at 221 N Main St adds up to a total of 3,400 square feet across 2 listing(s). The largest individual space listed offers 2,200 square feet. Property use types available for lease at this property include: office.
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Learn More about 221 N Main St
221 N Main St is located in the Worcester Springfield market and pertains to the 01760 zip code. The property incorporates a total of 3,400 square feet of space.
Interested in researching more about this property? Access in-depth research on 221 N Main St, including ownership details, transaction history, property characteristics, taxes, mortgage data, violations and more by creating a free account and viewing the full property report.
