221 N Main St
221 N Main St, Natick, MA 01760
220 North Main Street in Natick offers renovated, flexible office space in a highly visible location on Route 27/9, with direct access to Natick Mall, Route 9, and major regional highways.
The three-story, locally owned and managed building features modern upgrades, on-site showers, ample parking, and walkable amenities—an efficient suburban office option for businesses seeking convenience, access, and a professional setting.
Rental Details
- Number of spaces 2
- Total square feet available 3,400 SF
- For Lease Price on request
- Space Type Office
- Latest Update Sep 8, 2026
Reach out to the broker for more info on lease terms and amenities
True
2 Spaces Available
| Space Name | Space Type | Lease Rate | Total Space | Floor | Lease Type | |
|---|---|---|---|---|---|---|
| Space Available | Office | Price on request | 1,200 SF | - | - | |
| Space Available | Office | Price on request | 2,200 SF | - | - |
Space Available
- Space Type
- Office
- Lease Rate
- Price on request
- Total Space
- 1,200 SF
Space Available
- Space Type
- Office
- Lease Rate
- Price on request
- Total Space
- 2,200 SF
Contacts
R.W. Holmes
R.W. Holmes
Building Details
- For Lease Price on request
- Property Type Office
- Property Size 28,465 SF
- Additional Rent Price on request
- Date Updated Sep 8, 2026
Location
- City Natick, MA
- Neighborhood Natick
- Zip Code 01760
- Market Worcester Springfield
-
Walk score 73/100 Very Walkable -
Bike score 55/100 Bikeable
Points of Interest
Natick Center
1.23 miles
West Natick
2.10 miles
Framingham
3.58 miles
Wellesley Hills
4.24 miles
Wellesley Farms
4.65 miles
Needham Heights
6.31 miles
Eliot
7.39 miles
Hersey
7.55 miles
Waltham
8.08 miles
Southborough
8.82 miles
Autel
0.77 miles
Gulf
0.78 miles
Sunoco
1.08 miles
Speedway
1.20 miles
Cumberland Farms
1.35 miles
Mobil
1.40 miles
Mabardy's Gulf
1.45 miles
Shell
1.74 miles
Tesla Supercharger
1.81 miles
ChargePoint
5.70 miles
MathWorks Apple Hill West Garage
0.32 miles
MathWorks Apple Hill East Garage
0.49 miles
Car Parking
0.76 miles
Truck Parking
0.76 miles
Lakeside Parking Garage
0.89 miles
Cochituate North Lot
1.15 miles
Parking Deck C
1.18 miles
Parking Deck D
1.22 miles
Parking Deck E
1.28 miles
Premium Parking Deck B
1.28 miles
Enterprise
0.32 miles
ScrubaDub
1.33 miles
Wellesley Car Wash
3.70 miles
The Clean Machine
4.46 miles
Enterprise rent-a-car
7.67 miles
Waltham Car Wash
8.13 miles
Quick & Clean Car Wash
8.47 miles
Zipcar
8.71 miles
Perfection Car Wash
9.07 miles
Five Guys
0.00 miles
Panera Bread
0.01 miles
Chipotle
0.07 miles
Dunkin'
0.12 miles
Chuck E. Cheese's
0.17 miles
Culinary Delights
0.19 miles
Theo's
0.19 miles
Krua Thai
0.19 miles
Pizza Hut
0.21 miles
Mandarin Cafe
0.32 miles
Stop & Shop
0.06 miles
Burlington
1.08 miles
ALDI
1.10 miles
Donelan's
1.11 miles
Nordstrom
1.21 miles
Shopper's Find
1.26 miles
Natick Mall
1.27 miles
Macy's
1.44 miles
Roche Bros.
1.67 miles
TJ Maxx
1.77 miles
Natick Fire Department
1.07 miles
Natick Police Department
1.35 miles
Wayland Fire Department
1.44 miles
CVS Pharmacy
1.46 miles
Walgreens
1.66 miles
MetroWest Medical Center: Leonard Morse Hospital
1.87 miles
Andrews Pharmacy
2.35 miles
Framingham Fire Department
2.47 miles
Campus Police
2.57 miles
State Police Station H-2, Framingham
2.84 miles
Listing Summary
-
Available Office Space Office space currently available at 221 N Main St adds up to a total of 3,400 square feet across 2 spaces. The largest individual space listed offers 2,200 square feet.
Property use types available for lease at this property include: office.
-
Property Details The property incorporates a total of 28,465 square feet of space.
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